Barker pioneered the idea that the epidemic of coronary heart disease in Western countries
in the 20th century, which paradoxically coincided with improved standards of living and …

A poorly functioning placenta results in impaired exchanges of oxygen, nutrition, wastes and
hormones between the mother and her fetus. This can lead to restriction of fetal growth …

Exposure to a sub-optimal environment in the womb can result in poor fetal growth and
impair the normal development of organs. The kidney, specifically the process of …

Alcohol during pregnancy can impair fetal development and result in offspring with
neurodevelopmental deficits. Less is known about how low to moderate alcohol exposure …

Background This study investigated the effect of uteroplacental insufficiency (UPI) on renal
development by detecting metabolic alterations in the kidneys of rats with intrauterine growth …

Linoleic acid (LA), an n-6 polyunsaturated fatty acid (PUFA), is obtained from the maternal
diet during pregnancy, and is essential for normal fetal growth and development. A maternal …

Intrauterine growth restriction (IUGR) due to uteroplacental insufficiency results in a placenta
that is unable to provide adequate nutrients and oxygen to the fetus. These growth-restricted …

Research question What is the effect of in-vitro fertilization (IVF) on long-term health of
offspring kidney? Design We established an IVF mouse model and subsequently observed …

When in late autumn 1944 the failed allied operation I Market Garden i trapped allied forces
fighting in the Netherlands on one side of the river Rhine, it shattered all their hopes of …

In healthy adults, Epo is produced by the kidneys, while Epo expression in the liver is only
induced under extreme circumstances like severe hypoxia, VHL or PHD inhibition or in end …