TGF-β signaling and resistance to cancer therapy
M Zhang, YY Zhang, Y Chen, J Wang… - Frontiers in Cell and …, 2021 - frontiersin.org
The transforming growth factor β (TGF-β) pathway, which is well studied for its ability to
inhibit cell proliferation in early stages of tumorigenesis while promoting epithelial …
inhibit cell proliferation in early stages of tumorigenesis while promoting epithelial …
Transforming growth factor-β signaling pathway in colorectal cancer and its tumor microenvironment
Y Itatani, K Kawada, Y Sakai - International journal of molecular sciences, 2019 - mdpi.com
Transforming growth factor-beta (TGF-β) signaling is one of the important cellular pathways
that play key roles for tissue maintenance. In particular, it is important in the context of …
that play key roles for tissue maintenance. In particular, it is important in the context of …
Therapeutic advancements in targeting BCL-2 family proteins by epigenetic regulators, natural, and synthetic agents in cancer
Cancer is amongst the deadliest and most disruptive disorders, having a much higher death
rate than other diseases worldwide. Human cancer rates continue to rise, thereby posing the …
rate than other diseases worldwide. Human cancer rates continue to rise, thereby posing the …
BCL-w: apoptotic and non-apoptotic role in health and disease
ML Hartman, M Czyz - Cell Death & Disease, 2020 - nature.com
The BCL-2 family of proteins integrates signals that trigger either cell survival or apoptosis.
The balance between pro-survival and pro-apoptotic proteins is important for tissue …
The balance between pro-survival and pro-apoptotic proteins is important for tissue …
SMAD4 loss in colorectal cancer patients correlates with recurrence, loss of immune infiltrate, and chemoresistance
Purpose: SMAD4 has shown promise in identifying patients with colorectal cancer at high
risk of recurrence or death. Experimental Design: A discovery cohort and independent …
risk of recurrence or death. Experimental Design: A discovery cohort and independent …
[HTML][HTML] Piperlongumine induces ROS mediated cell death and synergizes paclitaxel in human intestinal cancer cells
Piperlongumine (PL), a herbal drug extracted from long pepper (Piper longum L), is known
for its anti-inflammatory and anti-cancer properties. Although, its anti-cancer potential has …
for its anti-inflammatory and anti-cancer properties. Although, its anti-cancer potential has …
Large-scale profiling of kinase dependencies in cancer cell lines
J Campbell, CJ Ryan, R Brough, I Bajrami… - Cell reports, 2016 - cell.com
One approach to identifying cancer-specific vulnerabilities and therapeutic targets is to
profile genetic dependencies in cancer cell lines. Here, we describe data from a series of …
profile genetic dependencies in cancer cell lines. Here, we describe data from a series of …
Association of SMAD4 mutation with patient demographics, tumor characteristics, and clinical outcomes in colorectal cancer
SMAD4 is an essential mediator in the transforming growth factor-β pathway. Sporadic
mutations of SMAD4 are present in 2.1–20.0% of colorectal cancers (CRCs) but data are …
mutations of SMAD4 are present in 2.1–20.0% of colorectal cancers (CRCs) but data are …
Adjuvant chemotherapy for stage II colon cancer
SE Rebuzzi, G Pesola, V Martelli, AF Sobrero - Cancers, 2020 - mdpi.com
Simple Summary Stage II colon cancer is defined as an early stage of the tumor disease,
without the involvement of lymph nodes or distant organs. In this group of patients, surgery …
without the involvement of lymph nodes or distant organs. In this group of patients, surgery …