Oxidative stress in skin plays a major role in the aging process. This is true for intrinsic aging
and even more for extrinsic aging. Although the results are quite different in dermis and …

Dynamic remodeling of the extracellular matrix (ECM) is essential for development, wound
healing and normal organ homeostasis. Life-threatening pathological conditions arise when …

Background: Diastolic dysfunction (DD) is associated with the development of heart failure
and contributes to the pathogenesis of other cardiac maladies, including atrial fibrillation …

Ageing of human skin may result from both the passage of time (intrinsic ageing) and from
cumulative exposure to external influences (extrinsic ageing) such as ultraviolet radiation …

One of the most important functions of skin is to act as a protective barrier. To fulfill this role,
the structural integrity of the skin depends on the dermal-epidermal junction—a complex …

Abstract The International League of Dermatological Societies (ILDS), a global, not-for-profit
organization representing 157 dermatological societies worldwide, has identified the …

Cancer development and progression are closely associated with changes both in the
mechano-cellular phenotype of cancer and stromal cells and in the extracellular matrix …

Neocortical expansion, thought to underlie the cognitive traits unique to humans, is
accompanied by cortical folding. This folding starts around gestational week (GW) 20, but …

Collagen fibrils are the major tensile element in vertebrate tissues, in which they occur as
ordered bundles in the extracellular matrix. Abnormal fibril assembly and organization …

Changes in the mechanical properties of dermis occur during skin aging or tissue
remodeling and affect the activity of resident fibroblasts. With the aim to establish elastic …