Central nervous system (CNS) innate immunity plays essential roles in infections,
neurodegenerative diseases, and brain or spinal cord injuries. Astrocytes and microglia are …

Bacteria in the genus Brucella are important human and veterinary pathogens. The abortion
and infertility they cause in food animals produce economic hardships in areas where the …

Background: Brucella are small, nonmotile, intracellular, and aerobic gram-negative
bacteria. Of the 10 species that currently form the genus Brucella, 5 were shown to be …

Asthma is one of the most common inflammatory diseases characterized by airway
hyperresponsiveness, inflammation, and remodeling. Morin, an active ingredient obtained …

Microglia are the resident tissue macrophages of the central nervous system (CNS). Recent
findings point out that in the steady state the major role of microglia, is to instruct and …

Brucella spp. impedes the production of pro-inflammatory cytokines by its outer membrane
protein Omp25 in order to promote survival and immune evasion. However, how Omp25 …

The innate immune system is essential for the detection and elimination of bacterial
pathogens. Upon inflammasome activation, caspase-1 cleaves pro-IL-1β and pro-IL-18 to …

Subacute poisoning of 1, 2-dichloroethane (1, 2-DCE) has become a serious occupational
problem in China, and brain edema is its main pathological consequence, but little is known …

Brucella spp. are facultatively intracellular bacteria that can infect, survive, and multiply in
various host cell types in vivo and/or in vitro. The genus Brucella has markedly expanded in …

Dendritic cells (DCs) orchestrate host defenses against microorganisms. In infectious
diseases due to intracellular bacteria, the inefficiency of the immune system to eradicate …