Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial
inflammation, pannus formation, and bone and cartilage damage. It has a high disability …

Recent studies link changes in energy metabolism with the fate of pluripotent stem cells
(PSC s). Safe use of PSC derivatives in regenerative medicine requires an enhanced …

Male fertility is driven by spermatogonial stem cells (SSCs) that self-renew while also giving
rise to differentiating spermatogonia. Spermatogonial transitions are accompanied by a shift …

The tricarboxylic acid (TCA) cycle is a primordial metabolic pathway that is conserved from
bacteria to humans. Although this network is often viewed primarily as an energy producing …

Abstract α-Ketoglutarate (AKG) also known as 2-oxoglutarate is an essential metabolite in
virtually all organisms as it participates in a variety of biological processes including anti …

Stem cells are defined by their ability to self-renew and differentiate, both shown in multiple
studies to be regulated by metabolic processes. To decipher metabolic signatures of self …

Just over ten years have passed since the seminal Takahashi‐Yamanaka paper, and while
most attention nowadays is on induced, embryonic, and cancer stem cells, much of the …

Reprogramming of 'adult'differentiated somatic cells to 'embryonic'pluripotent stem cells
accompanied by increased rate of glycolysis. Conversely, glycolysis triggers accumulation of …

Wernicke's encephalopathy (WE) is a major central nervous system disorder resulting from
thiamine deficiency (TD) in which a number of brain regions can develop serious damage …

Abstract Development of manganism (also known as manganese neurotoxicity) is a major
complication of manganese exposure in which neurological dysfunction is linked to …