Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

MS analysis of intact protein complexes has emerged as an established technology for
assessing the composition and connectivity within dynamic, heterogeneous multiprotein …

Since its inception in 1994, The RNA Modification Database (RNAMDB, http://rna-mdb. cas.
albany. edu/RNAmods/) has served as a focal point for information pertaining to naturally …

Integrative structural biology attempts to model the structures of protein complexes that are
challenging or intractable by classical structural methods (due to size, dynamics, or …

Chemical crosslinking in combination with mass spectrometry has matured into an
alternative approach to derive low-resolution structural information of proteins and protein …

CID-MS/MS cleavable cross-linkers hold an enormous potential for an automated analysis of
cross-linked products, which is essential for conducting structural proteomics studies. The …

The identification of crosslinks by mass spectrometry has recently been established as an
integral part of the hybrid structural analysis of protein complexes and networks. The …

RATIONALE Chemical cross‐linking in combination with a mass spectrometric analysis of
the created cross‐linked products is an area of growing interest for deriving low‐resolution …

A combination of covalent labeling techniques and mass spectrometry (MS) is currently a
progressive approach for deriving insights related to the mapping of protein surfaces or …

Two-dimensional mass spectrometry (2D MS) is a multiplexed tandem mass spectrometry
method that does not rely on ion isolation to correlate the precursor and fragment ions. On a …