CD36 is a type 2 cell surface scavenger receptor widely expressed in many immune and
non-immune cells. It functions as both a signaling receptor responding to DAMPs and …

Cellular metabolism constitutes a fundamental process in biology. During tumor initiation
and progression, each cellular component in the cancerous niche undergoes dramatic …

Background Chimeric antigen receptor (CAR) T-cell therapy using brexucabtagene
autoleucel (BA) induces remission in many patients with mantle cell lymphoma (MCL), and …

Myeloid-derived suppressor cells (MDSCs) are a group of heterogeneous cells which are
abnormally accumulated during the differentiation of myeloid cells. Immunosuppression is …

Tumor cells possess complex immune evasion mechanisms to evade immune system
attacks, primarily through metabolic reprogramming, which significantly alters the tumor …

Mycobacterium tuberculosis (Mtb) and SARS-CoV-2 (CoV2) are the leading causes of death
due to infectious disease. Although Mtb and CoV2 both cause serious and sometimes fatal …

Aberrant lipid metabolism is nonnegligible for tumor cells to adapt to the tumor
microenvironment (TME). It plays a significant role in the amount and function of immune …

Introduction Multiple myeloma (MM) is still an incurable plasma cell malignancy. The efficacy
of immunotherapy on MM remains unsatisfactory, and the underlying molecular mechanisms …

Therapeutic resistance is a major obstacle to successful treatment or effective containment
of cancer. Peroxisome proliferator-activated receptors (PPARs) play an essential role in …

The Proviral Integration site for Moloney murine leukemia virus (PIM) kinases is a family of
serine/threonine kinases that regulates numerous signaling networks that promote cell …