Autophagy is a conserved lysosomal pathway for the degradation of cytoplasmic
components. Basal autophagy in kidney cells is essential for the maintenance of kidney …

The autophagic pathway involves the encapsulation of substrates in double-membraned
vesicles, which are subsequently delivered to the lysosome for enzymatic degradation and …

Zoonomia is the largest comparative genomics resource for mammals produced to date. By
aligning genomes for 240 species, we identify bases that, when mutated, are likely to affect …

Renal tubulointerstitial fibrosis was a crucial pathological feature of diabetic nephropathy
(DN), and renal tubular injury might associate with abnormal mitophagy. In this study, we …

Globally, diabetes is the leading cause of chronic kidney disease and end-stage renal
disease, which are major risk factors for cardiovascular disease and death. Despite this …

Mitochondria play a key role in maintaining cellular metabolic homeostasis. These
organelles have a high plasticity and are involved in dynamic processes such as …

Mitochondria play a crucial role in tubular injury in diabetic kidney disease (DKD). MitoQ is a
mitochondria-targeted antioxidant that exerts protective effects in diabetic mice, but the …

Dysregulation of autophagy in diabetic kidney disease (DKD) has been reported, but the
underlying mechanism and its pathogenic role remain elusive. We show that autophagy was …

Diabetic kidney disease (DKD) is a devastating microvascular complication associated with
diabetes mellitus. Recently, the major focus of glomerular lesions of DKD has partly shifted …

Impaired macroautophagy/autophagy has been implicated in experimental and human
nonalcoholic steatohepatitis (NASH). However, the mechanism underlying autophagy …