Analyses of steroid receptors are important for understanding molecular details of
transcriptional control, as well as providing insight as to how an individual transacting factor …

A key property of complex biological systems is the presence of interaction networks formed
by its different components, primarily proteins. These are crucial for all levels of cellular …

Transcription factors (TFs) orchestrate the gene expression programs that define each cell's
identity. The canonical TF accomplishes this with two domains, one that binds specific DNA …

Gene expression is controlled by transcription factors (TFs) that consist of DNA-binding
domains (DBDs) and activation domains (ADs). The DBDs have been well characterized …

A wide variety of biological experiments rely on the ability to express an exogenous gene in
a transgenic animal at a defined level and in a spatially and temporally controlled pattern …

We have designed a system for targeted gene expression that allows the selective activation
of any cloned gene in a wide variety of tissueand cell-specific patterns. The gene encoding …

PROTEIN-protein interactions between two proteins have generally been studied using
biochemical techniques such as crosslinking, co-immunoprecipitation and co-fractionation …

The function and activity of a protein are often modulated by other proteins with which it
interacts. This review is intended as a practical guide to the analysis of such protein-protein …

Identifying the functional elements encoded in a genome is one of the principal challenges
in modern biology. Comparative genomics should offer a powerful, general approach. Here …

We describe a method that detects proteins capable of interacting with a known protein and
that results in the immediate availability of the cloned genes for these interacting proteins …