Kidney size and glomerular filtration rate (GFR) often increase with the onset of diabetes,
and elevated GFR is a risk factor for the development of diabetic kidney disease …

Epicardial adipose tissue has unique properties that distinguish it from other depots of
visceral fat. Rather than having distinct boundaries, the epicardium shares an unobstructed …

Sodium-glucose cotransporter-2 (SGLT2) is selectively expressed in the human kidney,
where it executes reabsorption of filtered glucose with a high capacity; it may be overactive …

Traditional treatments for type 1 and type 2 diabetes are often associated with side effects,
including weight gain and hypoglycaemia that may offset the benefits of blood glucose …

Background Sodium‐glucose cotransporter 2 (SGLT2) inhibitors are a novel class of
antihyperglycemic agents that improve glycemic control by increasing glycosuria. Additional …

The kidney plays an important role in glucose homeostasis via gluconeogenesis, glucose
utilization, and glucose reabsorption from the renal glomerular filtrate. After an overnight fast …

The kidneys filter large amounts of glucose. To prevent the loss of this valuable fuel, the
tubular system of the kidney, particularly the proximal tubule, has been programmed to …

Diabetes mellitus contributes greatly to morbidity, mortality, and overall health care costs. In
major part, these outcomes derive from the high incidence of progressive kidney dysfunction …

Cardiovascular (CV) disease and heart failure (HF) are the leading cause of mortality in type
2 diabetes (T2DM), a metabolic disease which represents a fast-growing health challenge …

Sodium glucose cotransporter 2 inhibition in the diabetic ki... : Current Opinion in Nephrology and
Hypertension Sodium glucose cotransporter 2 inhibition in the diabetic kidney: an update …