Organic cation transporters in health and disease
H Koepsell - Pharmacological reviews, 2020 - ASPET
The organic cation transporters (OCTs) OCT1, OCT2, OCT3, novel OCT (OCTN) 1, OCTN2,
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …
multidrug and toxin exclusion (MATE) 1, and MATE kidney-specific 2 are polyspecific …
Emerging roles of the human solute carrier 22 family
SW Yee, KM Giacomini - Drug Metabolism and Disposition, 2022 - ASPET
The human solute carrier 22 family (SLC22), also termed the organic ion transporter family,
consists of 28 distinct multi-membrane spanning proteins, which phylogenetically cluster …
consists of 28 distinct multi-membrane spanning proteins, which phylogenetically cluster …
Molecular basis of polyspecific drug and xenobiotic recognition by OCT1 and OCT2
A wide range of endogenous and xenobiotic organic ions require facilitated transport
systems to cross the plasma membrane for their disposition. In mammals, organic cation …
systems to cross the plasma membrane for their disposition. In mammals, organic cation …
Update on drug-drug interaction at organic cation transporters: mechanisms, clinical impact, and proposal for advanced in vitro testing
H Koepsell - Expert Opinion on Drug Metabolism & Toxicology, 2021 - Taylor & Francis
Introduction: Organic cation transporters collectively called OCTs belong to three gene
families (SLC22A1 OCT1, SLC22A2 OCT2, SLC22A3 OCT3, SLC22A4 OCTN1, SLC22A5 …
families (SLC22A1 OCT1, SLC22A2 OCT2, SLC22A3 OCT3, SLC22A4 OCTN1, SLC22A5 …
General overview of organic cation transporters in brain
H Koepsell - Organic Cation Transporters in the Central Nervous …, 2021 - Springer
Abstract Inhibitors of Na+/Cl− dependent high affinity transporters for norepinephrine (NE),
serotonin (5-HT), and/or dopamine (DA) represent frequently used drugs for treatment of …
serotonin (5-HT), and/or dopamine (DA) represent frequently used drugs for treatment of …
Synthesis of dibenzocycloketones by acyl radical cyclization from aromatic carboxylic acids using methylene blue as a photocatalyst
H Jiang, G Mao, H Wu, Q An, M Zuo, W Guo, C Xu… - Green …, 2019 - pubs.rsc.org
An efficient intramolecular radical cyclization reaction via photoredox catalysis was
developed for the synthesis of dibenzocycloketone derivatives using methylene blue as a …
developed for the synthesis of dibenzocycloketone derivatives using methylene blue as a …
Designing drugs when there is low data availability: one-shot learning and other approaches to face the issues of a long-term concern
GC Verissimo, MSM Serafim… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Modern drug discovery is generally accessed by useful information from
previous large databases or uncovering novel data. The lack of biological and/or chemical …
previous large databases or uncovering novel data. The lack of biological and/or chemical …
Computational chemistry in structure-based solute carrier transporter drug design: Recent advances and future perspectives
G Tu, T Fu, G Zheng, B Xu, R Gou, D Luo… - Journal of chemical …, 2024 - ACS Publications
Solute carrier transporters (SLCs) are a class of important transmembrane proteins that are
involved in the transportation of diverse solute ions and small molecules into cells. There are …
involved in the transportation of diverse solute ions and small molecules into cells. There are …
Substrates and Inhibitors of the Organic Cation Transporter 3 and Comparison with OCT1 and OCT2
L Gebauer, O Jensen, J Brockmöller… - Journal of medicinal …, 2022 - ACS Publications
Organic cation transporters (OCTs) 1, 2, and 3 facilitate cellular uptake of structurally diverse
endogenous and exogenous substances. However, their substrate and inhibitor specificity …
endogenous and exogenous substances. However, their substrate and inhibitor specificity …
Drug-drug interactions at organic cation transporter 1
S Zhou, S Zeng, Y Shu - Frontiers in Pharmacology, 2021 - frontiersin.org
The interaction between drugs and various transporters is one of the decisive factors that
affect the pharmacokinetics and pharmacodynamics of drugs. The organic cation transporter …
affect the pharmacokinetics and pharmacodynamics of drugs. The organic cation transporter …