Antivirals targeting influenza A virus

K Das - Journal of medicinal chemistry, 2012 - ACS Publications
Flu is caused by influenza viruses. The primary defense against influenza A and B is through
vaccination. Seasonal flu viruses constantly undergo antigenic variations by changing their …

Synthesis, antimicrobial, and anti-HIV-1 activity of certain 5-(1-adamantyl)-2-substituted thio-1, 3, 4-oxadiazoles and 5-(1-adamantyl)-3-substituted aminomethyl-1, 3, 4 …

AA El-Emam, OA Al-Deeb, M Al-Omar… - Bioorganic & medicinal …, 2004 - Elsevier
The reaction of 5-(1-adamantyl)-1, 3, 4-oxadiazoline-2-thione 2 with iodoethane, 2-
dimethylaminoethyl chloride hydrochloride or 2-piperidinoethyl chloride hydrochloride in …

Synthesis, antimicrobial, and anti-inflammatory activities of novel 2-(1-adamantyl)-5-substituted-1, 3, 4-oxadiazoles and 2-(1-adamantylamino)-5-substituted-1, 3, 4 …

AA Kadi, NR El-Brollosy, OA Al-Deeb, EE Habib… - European journal of …, 2007 - Elsevier
Reaction of 1-adamantanecarbonyl chloride with certain carboxylic acid hydrazides in
pyridine yielded the corresponding N-acyl adamantane-1-carbohydrazide derivatives 3a–j …

Novel 4-thiazolidinone derivatives as potential antifungal and antibacterial drugs

K Omar, A Geronikaki, P Zoumpoulakis… - Bioorganic & medicinal …, 2010 - Elsevier
As part of ongoing studies in developing new antimicrobials, a class of structurally novel 4-
thiazolidinone derivatives incorporating three known bioactive nuclei such as thiazole …

Coordination compounds of pyrazolone‐based ligand: Design, characterization, biological evaluation, antitumor efficiency, and DNA binding evaluation supported by …

SA Ibrahim, A Ragab… - Applied Organometallic …, 2022 - Wiley Online Library
Abstract Cu (II), Ni (II), Mn (II), and Cr (III) chelates of the organic ligand named 3‐(furan‐2‐
yl)‐5‐oxo‐N, 1‐diphenyl‐4, 5‐dihydro‐1H‐pyrazole‐4‐carbothioamide ligand (abbreviated …

Anti‐influenza virus agents: Synthesis and mode of action

IM Lagoja, E De Clercq - Medicinal research reviews, 2008 - Wiley Online Library
Annual epidemics of influenza virus infection are responsible for considerable morbidity and
mortality, and pandemics are much more devastating. Considerable knowledge of viral …

Synthesis, antimicrobial and anti-inflammatory activities of novel 5-(1-adamantyl)-1, 3, 4-thiadiazole derivatives

AA Kadi, ES Al-Abdullah, IA Shehata, EE Habib… - European journal of …, 2010 - Elsevier
New 1-adamanyl-1, 3, 4-thiadiazole derivatives namely, 5-(1-adamantyl)-1, 3, 4-
thiadiazoline-2-thione 3, 5-(1-adamantyl)-3-(benzyl-or 4-substituted benzyl)-1, 3, 4 …

Green synthesis for new Co (II), Ni (II), Cu (II) and Cd (II) hydrazone-based complexes; characterization, biological activity and electrical conductance of nano-sized …

SD Al-Qahtani, A Alsoliemy, SJ Almehmadi… - Journal of Molecular …, 2021 - Elsevier
A series of new hydrazone complexes were prepared and perfectly elucidated to be 1: 1
molar ratio with Cd (II) complex, while 1: 2 (M: L) with Co (II), Ni (II) and Cu (II) complexes …

Spectroscopic characterization, cyclic voltammetry, biological investigations, MOE, and gaussian calculations of VO (II), Cu (II), and Cd (II) heteroleptic complexes

AG Al-Harazie, EA Gomaa, RR Zaky… - ACS …, 2023 - ACS Publications
A novel hydrazone ligand (o-H2BMP) N-(benzo [d] thiazol-2-yl)-3-oxo-3-(2-(1-(pyridin-2-yl)
ethylidene) hydrazinyl) propanamide alongside its Cu (II), Cd (II), and VO (II) complexes …

Conductometry of nano-sized zinc sulfate; synthesis and characterization of new hydrazone complexes: conformational and in-vitro assay

K Alkhamis, A Alsoliemy, MM Aljohani… - Journal of Molecular …, 2021 - Elsevier
Hydrazone derivative was used to prepare 1: 1 M ratio with Cr (III) & Co (II) ions as well as 1:
2 ratio with Zn (II) & Cd (II) ions. The ligand (H 2 L) coordinated as bidentate/tridentate via …