Chemosensory signal transduction in Caenorhabditis elegans

DM Ferkey, P Sengupta, ND L'Etoile - Genetics, 2021 - academic.oup.com
Chemosensory neurons translate perception of external chemical cues, including odorants,
tastants, and pheromones, into information that drives attraction or avoidance motor …

C. elegans in high-throughput drug discovery

LP O'Reilly, CJ Luke, DH Perlmutter… - Advanced drug delivery …, 2014 - Elsevier
Caenorhabditis elegans has been proven to be a useful model organism for investigating
molecular and cellular aspects of numerous human diseases. More recently, investigators …

High-content behavioral analysis of Caenorhabditis elegans in precise spatiotemporal chemical environments

DR Albrecht, CI Bargmann - Nature methods, 2011 - nature.com
To quantitatively understand chemosensory behaviors, it is desirable to present many
animals with repeatable, well-defined chemical stimuli. To that end, we describe a …

Lifespan-on-a-chip: microfluidic chambers for performing lifelong observation of C. elegans

SE Hulme, SS Shevkoplyas, AP McGuigan, J Apfeld… - Lab on a Chip, 2010 - pubs.rsc.org
This article describes the fabrication of a microfluidic device for the liquid culture of many
individual nematode worms (Caenorhabditis elegans) in separate chambers. Each chamber …

Microfluidics for understanding model organisms

N Frey, UM Sönmez, J Minden, P LeDuc - Nature communications, 2022 - nature.com
New microfluidic systems for whole organism analysis and experimentation are catalyzing
biological breakthroughs across many fields, from human health to fundamental biology …

A microfluidic platform for high-sensitivity, real-time drug screening on C. elegans and parasitic nematodes

JA Carr, A Parashar, R Gibson, AP Robertson… - Lab on a Chip, 2011 - pubs.rsc.org
This paper describes a new microfluidic platform for screening drugs and their dose
response on the locomotion behavior of free living nematodes and parasitic nematodes. The …

Femtosecond laser nanoaxotomy lab-on-a-chip for in vivo nerve regeneration studies

SX Guo, F Bourgeois, T Chokshi, NJ Durr, MA Hilliard… - Nature …, 2008 - nature.com
A thorough understanding of nerve regeneration in Caenorhabditis elegans requires
performing femtosecond laser nanoaxotomy while minimally affecting the worm. We present …

Chip technologies for screening chemical and biological agents against plant-parasitic nematodes

AQ Beeman, ZL Njus, S Pandey, GL Tylka - Phytopathology, 2016 - Am Phytopath Society
Plant-parasitic nematodes cause substantial damage to agricultural crops worldwide. Long-
term management of these pests requires novel strategies to reduce infection of host plants …

Controlling airborne cues to study small animal navigation

M Gershow, M Berck, D Mathew, L Luo, EA Kane… - Nature …, 2012 - nature.com
Small animals such as nematodes and insects analyze airborne chemical cues to infer the
direction of favorable and noxious locations. In these animals, the study of navigational …

Gait Modulation in C. elegans: An Integrated Neuromechanical Model

JH Boyle, S Berri, N Cohen - Frontiers in computational neuroscience, 2012 - frontiersin.org
Equipped with its 302-cell nervous system, the nematode Caenorhabditis elegans adapts its
locomotion in different environments, exhibiting so-called swimming in liquids and crawling …