Advances in areas that include genomics, systems biology, protein structure determination
and artificial intelligence provide new opportunities for target-based antibacterial drug …

The absorption of orally administered drug products is a complex, dynamic process,
dependant on a range of biopharmaceutical properties; notably the aqueous solubility of a …

Computational drug discovery methods provide valuable insights into the understanding of
protein–ligand interaction systems in a virtual manner. Molecular docking and …

Guided by the structural optimization principle and the promising anticancer effect of the
quinoxaline nucleus, a new series of novel HDAC inhibitors were designed and …

Target identification is an important step in drug discovery, and computer-aided drug target
identification methods are attracting more attention compared with traditional drug target …

Bacterial vaginosis (BV), primarily attributed to Gardnerella vaginalis, poses significant
challenges due to antibiotic resistance and suboptimal treatment outcomes. This study …

The oral drug bioavailability (BA) problems have remained inevitable over the years,
impairing drug efficacy and indirectly leading to eventual human morbidity and mortality …

Multicomponent reactions have emerged as an important approach for the synthesis of
diverse and complicated chemical compounds. They have various advantages over two …

A series of new isoxazolederivatives incorporating the sulfonate ester function has been
synthesized from 2-benzylidenebenzofuran-3 (2 H)-one, known as aurone. The synthesis of …

Insomnia is a sleep disorder in which you have trouble falling and/or staying asleep. This
research aims to evaluate the sedative effects of fraxin (FX) on sleeping mice induced by …