Reverse vaccinology: developing vaccines in the era of genomics
A Sette, R Rappuoli - Immunity, 2010 - cell.com
The sequence of microbial genomes made all potential antigens of each pathogen available
for vaccine development. This increased by orders of magnitude potential vaccine targets in …
for vaccine development. This increased by orders of magnitude potential vaccine targets in …
The pockets guide to HLA class I molecules
Human leukocyte antigens (HLA) are cell-surface proteins that present peptides to T cells.
These peptides are bound within the peptide binding cleft of HLA, and together as a …
These peptides are bound within the peptide binding cleft of HLA, and together as a …
HLA class I supertypes: a revised and updated classification
Background Class I major histocompatibility complex (MHC) molecules bind, and present to
T cells, short peptides derived from intracellular processing of proteins. The peptide …
T cells, short peptides derived from intracellular processing of proteins. The peptide …
Functional classification of class II human leukocyte antigen (HLA) molecules reveals seven different supertypes and a surprising degree of repertoire sharing across …
Previous studies have attempted to define human leukocyte antigen (HLA) class II
supertypes, analogous to the case for class I, on the basis of shared peptide-binding motifs …
supertypes, analogous to the case for class I, on the basis of shared peptide-binding motifs …
Quantitative peptide binding motifs for 19 human and mouse MHC class I molecules derived using positional scanning combinatorial peptide libraries
Background It has been previously shown that combinatorial peptide libraries are a useful
tool to characterize the binding specificity of class I MHC molecules. Compared to other …
tool to characterize the binding specificity of class I MHC molecules. Compared to other …
MHC class II epitope predictive algorithms
Major histocompatibility complex class II (MHC‐II) molecules sample peptides from the
extracellular space, allowing the immune system to detect the presence of foreign microbes …
extracellular space, allowing the immune system to detect the presence of foreign microbes …
Genome-wide B cell, CD4+, and CD8+ T cell epitopes that are highly conserved between human and animal coronaviruses, identified from SARS-CoV-2 as targets for …
S Prakash, R Srivastava, PG Coulon… - The Journal of …, 2021 - journals.aai.org
Over the last two decades, there have been three deadly human outbreaks of coronaviruses
(CoVs) caused by SARS-CoV, MERS-CoV, and SARS-CoV-2, which has caused the current …
(CoVs) caused by SARS-CoV, MERS-CoV, and SARS-CoV-2, which has caused the current …
Evaluation of MHC-II peptide binding prediction servers: applications for vaccine research
Background Initiation and regulation of immune responses in humans involves recognition
of peptides presented by human leukocyte antigen class II (HLA-II) molecules. These …
of peptides presented by human leukocyte antigen class II (HLA-II) molecules. These …
MHCcluster, a method for functional clustering of MHC molecules
The identification of peptides binding to major histocompatibility complexes (MHC) is a
critical step in the understanding of T cell immune responses. The human MHC genomic …
critical step in the understanding of T cell immune responses. The human MHC genomic …
Major histocompatibility complex class I binding predictions as a tool in epitope discovery
Over the last decade, in silico models of the major histocompatibility complex (MHC) class I
pathway have developed significantly. Before, peptide binding could only be reliably …
pathway have developed significantly. Before, peptide binding could only be reliably …