Deep learning in proteomics

B Wen, WF Zeng, Y Liao, Z Shi, SR Savage… - …, 2020 - Wiley Online Library
Proteomics, the study of all the proteins in biological systems, is becoming a data‐rich
science. Protein sequences and structures are comprehensively catalogued in online …

Toward an integrated machine learning model of a proteomics experiment

BA Neely, V Dorfer, L Martens, I Bludau… - Journal of proteome …, 2023 - ACS Publications
In recent years machine learning has made extensive progress in modeling many aspects of
mass spectrometry data. We brought together proteomics data generators, repository …

DeepLC can predict retention times for peptides that carry as-yet unseen modifications

R Bouwmeester, R Gabriels, N Hulstaert, L Martens… - Nature …, 2021 - nature.com
The inclusion of peptide retention time prediction promises to remove peptide identification
ambiguity in complex liquid chromatography–mass spectrometry identification workflows …

Deep learning neural network tools for proteomics

JG Meyer - Cell Reports Methods, 2021 - cell.com
Mass-spectrometry-based proteomics enables quantitative analysis of thousands of human
proteins. However, experimental and computational challenges restrict progress in the field …

Updated MS²PIP web server supports cutting-edge proteomics applications

A Declercq, R Bouwmeester, C Chiva… - Nucleic Acids …, 2023 - academic.oup.com
Interest in the use of machine learning for peptide fragmentation spectrum prediction has
been strongly on the rise over the past years, especially for applications in challenging …

Recent developments in data independent acquisition (DIA) mass spectrometry: application of quantitative analysis of the brain proteome

KW Li, MA Gonzalez-Lozano, F Koopmans… - Frontiers in molecular …, 2020 - frontiersin.org
Mass spectrometry is the driving force behind current brain proteome analysis. In a typical
proteomics approach, a protein isolate is digested into tryptic peptides and then analyzed by …

A comprehensive LFQ benchmark dataset on modern day acquisition strategies in proteomics

B Van Puyvelde, S Daled, S Willems, R Gabriels… - Scientific data, 2022 - nature.com
In the last decade, a revolution in liquid chromatography-mass spectrometry (LC-MS) based
proteomics was unfolded with the introduction of dozens of novel instruments that …

Cov-MS: a community-based template assay for mass-spectrometry-based protein detection in SARS-CoV-2 patients

B Van Puyvelde, K Van Uytfanghe, O Tytgat… - Jacs Au, 2021 - ACS Publications
Rising population density and global mobility are among the reasons why pathogens such
as SARS-CoV-2, the virus that causes COVID-19, spread so rapidly across the globe. The …

The age of data‐driven proteomics: how machine learning enables novel workflows

R Bouwmeester, R Gabriels, T Van Den Bossche… - …, 2020 - Wiley Online Library
A lot of energy in the field of proteomics is dedicated to the application of challenging
experimental workflows, which include metaproteomics, proteogenomics, data independent …

Scribe: Next generation library searching for DDA experiments

BC Searle, AE Shannon… - Journal of Proteome …, 2023 - ACS Publications
Spectrum library searching is a powerful alternative to database searching for data
dependent acquisition experiments, but has been historically limited to identifying previously …