Ribosome biogenesis is among the most resource-intensive cellular processes, with
ribosomal proteins accounting for up to half of all newly synthesized proteins in eukaryotic …

The internal environment of cells is molecularly crowded, which requires spatial
organization via subcellular compartmentalization. These compartments harbor specific …

Arsenic contamination is extremely threatening to the global public health. It was reported
that sodium arsenite exposure induces serious kidney injury. However, the underlying …

HAC1 encodes a transcription factor that is the central effector of the unfolded protein
response (UPR) in budding yeast. When the UPR is inactive, HAC1 mRNA is stored as an …

Mitochondria play a crucial role in spermatogenesis and are regulated by several
mitochondrial fusion proteins. However, their functional importance associated with their …

Tumour-promoting inflammation is a hallmark of cancer, and chronic inflammatory disease
increases the risk of cancer. In this context, MYD88, a downstream signalling molecule of …

Eukaryotic cells maintain proteostasis through mechanisms that require cytoplasmic and
mitochondrial translation. Genetic defects affecting cytoplasmic translation perturb synapse …

Ribosome biogenesis is among the most resource-intensive cellular processes, with
ribosomal proteins accounting for up to half of all newly synthesized proteins in eukaryotic …

Protein synthesis is a highly regulated essential process. As such, it is subjected to
substantial regulation in response to stress. One hallmark of the Integrated Stress Response …

Polysome fractionation by sucrose density gradient centrifugation is a powerful tool that can
be used to create ribosome profiles, identify specific mRNAs being translated by ribosomes …