Over the past decade, the most significant, conceptual advances in the field of fluorination
were enabled most prominently by organo‐and transition‐metal catalysis. The most …

Fluorinated compounds are synthesized in pharmaceutical research on a routine basis and
many marketed compounds contain fluorine. The present review summarizes some of the …

The small and highly electronegative fluorine atom can play a remarkable role in medicinal
chemistry. Selective installation of fluorine into a therapeutic or diagnostic small molecule …

Die wichtigsten konzeptionellen Fortschritt auf dem Gebiet der Fluorierungen der letzten
zehn Jahre wurden durch die Organo‐und Übergangsmetallkatalyse ermöglicht. Die …

Increased incidence of type 2 diabetes mellitus and obesity has elevated the medical need
for new agents to treat these disease states. Resistance to the hormones insulin and leptin …

The aim of this review was to discuss an overview of type 2 diabetes; biology of PTP1B; role
of PTP1B in metabolic disorders; and recent updates in the development of PTP1B inhibitors …

Protein tyrosine phosphatases (PTPs) are signaling enzymes that control a diverse array of
cellular processes. Malfunction of PTP activity is associated with a number of human …

The phosphate moiety (PO4-2) is the common structural motif of a wide range of natural
phosphorus-based biologically active compounds, which play important roles as metabolic …

The protein tyrosine phosphatases (PTPs) constitute a family of closely related key
regulatory enzymes that dephosphorylate phosphotyrosine residues in their protein …

Background Gold nanoparticles are known for their many applications in the fields of
therapeutics and diagnosis. Methods This article focuses mainly on the green method of …