Multidrug evolutionary strategies to reverse antibiotic resistance
BACKGROUND Antibiotics are among the most important tools in medicine, but their efficacy
is threatened by the evolution of resistance. Since the earliest days of antibiotics, resistance …
is threatened by the evolution of resistance. Since the earliest days of antibiotics, resistance …
Within-host evolution of bacterial pathogens
Whole-genome sequencing has opened the way for investigating the dynamics and
genomic evolution of bacterial pathogens during the colonization and infection of humans …
genomic evolution of bacterial pathogens during the colonization and infection of humans …
[HTML][HTML] Adaptive evolution within gut microbiomes of healthy people
Natural selection shapes bacterial evolution in all environments. However, the extent to
which commensal bacteria diversify and adapt within the human gut remains unclear. Here …
which commensal bacteria diversify and adapt within the human gut remains unclear. Here …
Staphylococcus aureus and Staphylococcus epidermidis strain diversity underlying pediatric atopic dermatitis
AL Byrd, C Deming, SKB Cassidy… - Science translational …, 2017 - science.org
The heterogeneous course, severity, and treatment responses among patients with atopic
dermatitis (AD; eczema) highlight the complexity of this multifactorial disease. Prior studies …
dermatitis (AD; eczema) highlight the complexity of this multifactorial disease. Prior studies …
[HTML][HTML] Temporal stability of the human skin microbiome
Biogeography and individuality shape the structural and functional composition of the
human skin microbiome. To explore these factors' contribution to skin microbial community …
human skin microbiome. To explore these factors' contribution to skin microbial community …
Convergent evolution and adaptation of Pseudomonas aeruginosa within patients with cystic fibrosis
Little is known about how within-host evolution compares between genotypically different
strains of the same pathogenic species. We sequenced the whole genomes of 474 …
strains of the same pathogenic species. We sequenced the whole genomes of 474 …
An integrated metagenomics pipeline for strain profiling reveals novel patterns of bacterial transmission and biogeography
We present the M etagenomic I ntra-species D iversity A nalysis S ystem (MIDAS), which is
an integrated computational pipeline for quantifying bacterial species abundance and strain …
an integrated computational pipeline for quantifying bacterial species abundance and strain …
Evolutionary dynamics of bacteria in the gut microbiome within and across hosts
Gut microbiota are shaped by a combination of ecological and evolutionary forces. While the
ecological dynamics have been extensively studied, much less is known about how species …
ecological dynamics have been extensively studied, much less is known about how species …
[HTML][HTML] Anatomy promotes neutral coexistence of strains in the human skin microbiome
What enables strains of the same species to coexist in a microbiome? Here, we investigate
whether host anatomy can explain strain co-residence of Cutibacterium acnes, the most …
whether host anatomy can explain strain co-residence of Cutibacterium acnes, the most …
Population genomics of bacterial host adaptation
Some bacteria can transfer to new host species, and this poses a risk to human health.
Indeed, an estimated 60% of all human pathogens have originated from other animal …
Indeed, an estimated 60% of all human pathogens have originated from other animal …