Point estimation for adaptive trial designs I: A methodological review
DS Robertson, B Choodari‐Oskooei… - Statistics in …, 2023 - Wiley Online Library
Recent FDA guidance on adaptive clinical trial designs defines bias as “a systematic
tendency for the estimate of treatment effect to deviate from its true value,” and states that it is …
tendency for the estimate of treatment effect to deviate from its true value,” and states that it is …
Efficient adaptive designs for clinical trials of interventions for COVID-19
N Stallard, L Hampson, N Benda… - Statistics in …, 2020 - Taylor & Francis
The COVID-19 pandemic has led to an unprecedented response in terms of clinical
research activity. An important part of this research has been focused on randomized …
research activity. An important part of this research has been focused on randomized …
[PDF][PDF] Point estimation for adaptive trial designs
DS Robertson, B Choodari-Oskooei, M Dimairo… - arXiv, 2021 - core.ac.uk
Recent FDA guidance on adaptive clinical trial designs defines bias as “a systematic
tendency for the estimate of treatment effect to deviate from its true value”, and states that it is …
tendency for the estimate of treatment effect to deviate from its true value”, and states that it is …
Low-complexity methods for estimation after parameter selection
N Harel, T Routtenberg - IEEE Transactions on Signal …, 2020 - ieeexplore.ieee.org
Statistical inference of multiple parameters often involves a preliminary parameter selection
stage. The selection stage has an impact on subsequent estimation, for example by …
stage. The selection stage has an impact on subsequent estimation, for example by …
Estimation of the selected treatment mean in two stage drop-the-losers design
Masihuddin, N Misra - Journal of Biopharmaceutical Statistics, 2024 - Taylor & Francis
ABSTRACT A common problem faced in clinical studies is that of estimating the effect of the
most effective (eg the one having the largest mean) treatment among k (≥ 2) available …
most effective (eg the one having the largest mean) treatment among k (≥ 2) available …
On estimating the selected treatment mean under a two‐stage adaptive design
Masihuddin, N Misra - Stat, 2023 - Wiley Online Library
Adaptive designs are commonly used in clinical and drug development studies for optimum
utilization of available resources. In this article, we consider the problem of estimating the …
utilization of available resources. In this article, we consider the problem of estimating the …
On Estimating the Selected Treatment Mean under a Two-Stage Adaptive Design
N Misra - arXiv preprint arXiv:2301.09124, 2023 - arxiv.org
Adaptive designs are commonly used in clinical and drug development studies for optimum
utilization of available resources. In this article, we consider the problem of estimating the …
utilization of available resources. In this article, we consider the problem of estimating the …
Point estimation for adaptive trial designs I: a methodological review
DS Robertson, B Choodari-Oskooei, M Dimairo… - arXiv preprint arXiv …, 2021 - arxiv.org
Recent FDA guidance on adaptive clinical trial designs defines bias as" a systematic
tendency for the estimate of treatment effect to deviate from its true value", and states that it is …
tendency for the estimate of treatment effect to deviate from its true value", and states that it is …