Ion mobility–mass spectrometry

AB Kanu, P Dwivedi, M Tam, L Matz… - Journal of mass …, 2008 - Wiley Online Library
This review article compares and contrasts various types of ion mobility–mass spectrometers
available today and describes their advantages for application to a wide range of analytes …

Liquid chromatography/atmospheric pressure ionization–mass spectrometry in drug metabolism studies

R Kostiainen, T Kotiaho, T Kuuranne… - Journal of Mass …, 2003 - Wiley Online Library
The study of the metabolic fate of drugs is an essential and important part of the drug
development process. The analysis of metabolites is a challenging task and several different …

Online parallel accumulation–serial fragmentation (PASEF) with a novel trapped ion mobility mass spectrometer

F Meier, AD Brunner, S Koch, H Koch, M Lubeck… - Molecular & Cellular …, 2018 - ASBMB
In bottom-up proteomics, peptides are separated by liquid chromatography with elution peak
widths in the range of seconds, whereas mass spectra are acquired in about 100 …

Natural organic matter and the event horizon of mass spectrometry

N Hertkorn, M Frommberger, M Witt, BP Koch… - Analytical …, 2008 - ACS Publications
Soils, sediments, freshwaters, and marine waters contain natural organic matter (NOM), an
exceedingly complex mixture of organic compounds that collectively exhibit a nearly …

Deep learning the collisional cross sections of the peptide universe from a million experimental values

F Meier, ND Köhler, AD Brunner, JMH Wanka… - Nature …, 2021 - nature.com
The size and shape of peptide ions in the gas phase are an under-explored dimension for
mass spectrometry-based proteomics. To investigate the nature and utility of the peptide …

High-sensitivity ion mobility spectrometry/mass spectrometry using electrodynamic ion funnel interfaces

K Tang, AA Shvartsburg, HN Lee, DC Prior… - Analytical …, 2005 - ACS Publications
The utility of ion mobility spectrometry (IMS) for separation of mixtures and structural
characterization of ions has been demonstrated extensively, including in biological and …

From exogenous to endogenous: the inevitable imprint of mass spectrometry in metabolomics

EJ Want, A Nordström, H Morita… - Journal of proteome …, 2007 - ACS Publications
Mass spectrometry (MS) is an established technology in drug metabolite analysis and is now
expanding into endogenous metabolite research. Its utility derives from its wide dynamic …

Quantification in proteomics through stable isotope coding: a review

S Julka, F Regnier - Journal of proteome research, 2004 - ACS Publications
This review focuses on techniques for quantification and identification in proteomics by
stable isotope coding. Methods are examined for analyzing expression, post-translational …

Hybrid ion mobility and mass spectrometry as a separation tool

MA Ewing, MS Glover, DE Clemmer - Journal of Chromatography A, 2016 - Elsevier
Ion mobility spectrometry (IMS) coupled to mass spectrometry (MS) has seen spectacular
growth over the last two decades. Increasing IMS sensitivity and capacity with improvements …

Ion mobility spectrometry coupled with multi-capillary columns for metabolic profiling of human breath

JI Baumbach - Journal of breath research, 2009 - iopscience.iop.org
Recently, ion mobility spectrometry (IMS) started to be used for direct breath analysis with
respect to metabolic profiling, biomarker finding and gas trace analysis. The present review …