SRC homology 3 (SH3) domains are fundamental modules that enable the assembly of
protein complexes through physical interactions with a pool of proline-rich/noncanonical …

Platelet factors regulate wound healing and can signal from the blood to the brain,.
However, whether platelet factors modulate cognition, a highly valued and central …

Postsynaptic GABAergic receptors interact with various membrane and intracellular proteins
to mediate inhibitory synaptic transmission. They form structural and/or signaling synaptic …

Multiple sclerosis (MS) and its preclinical models are characterized by marked changes in
neuroplasticity, including excitatory/inhibitory imbalance and synaptic dysfunction that are …

Summary Rho GTP Exchange Factors (RhoGEFs) and Rho GTPase Activating Proteins
(RhoGAPs) are large families of molecules that regulate shape determination in all …

Epilepsy is a disorder characterized by an imbalance between excitability and inhibition,
leading to uncontrolled hyperexcitability of neurons in the central nervous system. Despite …

LMTK3 is a brain-specific transmembrane serine/threonine protein kinase that acts as a
scaffold for protein phosphatase-1 (PP1). Although LMKT3 has been identified as a risk …

Inhibitory signaling in the brain organizes the neural circuits that orchestrate how living
creatures interact with the world around them and how they build representations of objects …

X chromosome centromeric drive may explain the prevalence of polycystic ovary syndrome
and contribute to oocyte aneuploidy, menopause, and other conditions. The mammalian X …

Le bon fonctionnement du système nerveux central dépend d'une étroite connexion entre
excitation et inhibition neuronale. Des altérations du fonctionnement des synapses …