Predicting the effects of mutations in proteins is critical to many applications, from
understanding genetic disease to designing novel proteins to address our most pressing …

Dietary polysaccharides function not only as indispensable nutrients and energy sources for
the host organism but also as critical substrates for the gut microbiota. Gut microorganisms …

Proteostasis can be disturbed by mutations affecting folding and stability of the encoded
protein. An example is the ubiquitin ligase Parkin, where gene variants result in autosomal …

Bioreactors are crucial in industrial production, where enzyme catalysis typically occurs in
water and requires continuous heating, consuming significant energy. This study reports a …

Lipase activity from Aspergillus fumigatus (AFL) were modulated by an effector (HMD) that
was discovered for an allosteric site on the bioactive macromolecule. Experimental …

Abstract Crosslinked Enzyme Aggregates (CLEAs) are favored for their operational stability
and recyclability. However, the traditional CLEAs preparation may distort the enzyme's …

The one-step deconstruction of sucrose into uridine 5′-diphosphate-glucose (UDP-Glc), an
important sugar donor for transglycosylation, employing sucrose synthase (Susy) is …

High-throughput assays that efficiently link genotype and phenotype with high fidelity are
key to successful enzyme engineering campaigns. Among these assays, the …

The robustness and catalytic activity of superoxide dismutase (SOD) are still the main factors
limiting their application in industrial fields. This study aims to further improve the properties …

Protein design and engineering are crucial for advancements in biotechnology, medicine,
and sustainability. Machine learning (ML) models are used to design or enhance protein …