Glioblastoma is the most aggressive form of malignant brain tumor. Standard treatment
protocols and traditional immunotherapy are poorly effective as they do not significantly …

Simple Summary Oncolytic adenoviruses are engineered to selectively replicate in and
destroy cancer tissue. Moreover, these viruses are promising tools to restore antitumor …

Glioma tumors are one of the most devastating cancer types. Glioblastoma is the most
advanced stage with the worst prognosis. Current therapies are still unable to provide an …

Cancer virotherapy is a paradigm-shifting treatment modality based on virus-mediated
oncolysis and subsequent antitumor immune responses. Clinical trials of currently available …

Background Glioblastoma (GBM) is a devastating primary brain tumor with a highly
immunosuppressive tumor microenvironment, and treatment with oncolytic viruses (OVs) …

Introduction: Despite diverse treatment modalities and novel therapies, many cancers and
patients are not effectively treated. Cancer immunotherapy has recently achieved …

Introduction: Immune checkpoint inhibitors (ICI) have dramatically improved the outcome for
cancer patients across multiple tumor types. However the response rates to ICI monotherapy …

Oncolytic viruses are a promising treatment for patients with high-grade gliomas, but
neutralizing antibodies can limit their efficacy in patients with prior virus exposure or upon …

Ad5-delta-24-RGD is currently the most clinically advanced recombinant adenovirus (rAd)
for glioma therapy. We constructed a panel of fiber-modified rAds (Ad5RGD, Ad5/3, Ad5/35 …

One of the most prevalent primary malignant brain tumors is glioblastoma (GB). About 6
incidents per 100,000 people are reported annually. Most frequently, these tumors are …