Recent advances in co-amorphous drug formulations
Co-amorphous drug delivery systems have recently gained considerable interest in the
pharmaceutical field because of their potential to improve oral bioavailability of poorly water …
pharmaceutical field because of their potential to improve oral bioavailability of poorly water …
Amorphous solid dispersions: Rational selection of a manufacturing process
Amorphous products and particularly amorphous solid dispersions are currently one of the
most exciting areas in the pharmaceutical field. This approach presents huge potential and …
most exciting areas in the pharmaceutical field. This approach presents huge potential and …
Quality-by-design in hot melt extrusion based amorphous solid dispersions: An industrial perspective on product development
An industrially feasible approach to overcome the solubility and bioavailability limitations of
poorly soluble active pharmaceutical ingredients is the development of amorphous solid …
poorly soluble active pharmaceutical ingredients is the development of amorphous solid …
The application of temperature-composition phase diagrams for hot melt extrusion processing of amorphous solid dispersions to prevent residual crystallinity
DE Moseson, LS Taylor - International journal of pharmaceutics, 2018 - Elsevier
Hot melt extrusion (HME) can be used to produce amorphous solid dispersions (ASDs) at
temperatures below the drug's melting point if the drug and polymer exhibit melting point …
temperatures below the drug's melting point if the drug and polymer exhibit melting point …
Mold inserts for injection molding prototype applications fabricated via material extrusion additive manufacturing
As extrusion-based 3D printers are easily accessible and quickly adopted, their application
to plastics manufacturing as a prototype development tool continues to expand. In …
to plastics manufacturing as a prototype development tool continues to expand. In …
An approach for chemical stability during melt extrusion of a drug substance with a high melting point
Poorly water-soluble drug substances that exhibit high melting points are difficult to process
by melt extrusion due to chemical instability at high temperatures required for processing …
by melt extrusion due to chemical instability at high temperatures required for processing …
Predicting physical stability of ternary amorphous solid dispersions using specific mechanical energy in a hot melt extrusion process
This study focuses on the relationship between drug dissolution properties, physical stability
against recrystallization, and specific mechanical energy (SME) from a hot melt extrusion …
against recrystallization, and specific mechanical energy (SME) from a hot melt extrusion …
New strategies for improving the development and performance of amorphous solid dispersions
The understanding of amorphous solid dispersions has grown significantly in the past
decade. This is evident from the number of approved commercial amorphous solid …
decade. This is evident from the number of approved commercial amorphous solid …
Rheology guided rational selection of processing temperature to prepare copovidone–nifedipine amorphous solid dispersions via hot melt extrusion (HME)
The production of amorphous solid dispersions via hot melt extrusion (HME) relies on
elevated temperature and prolonged residence time, which can result in potential …
elevated temperature and prolonged residence time, which can result in potential …
Ternary amorphous solid dispersions containing a high-viscosity polymer and mesoporous silica enhance dissolution performance
M Hanada, SV Jermain, SA Thompson… - Molecular …, 2020 - ACS Publications
The aim of this study was to evaluate the benefits of a ternary amorphous solid dispersion
(ASD) that was designed as an immediate-release tablet with a high drug load (eg, 40 …
(ASD) that was designed as an immediate-release tablet with a high drug load (eg, 40 …