Glioblastoma (GBM) is the most aggressive malignant brain tumor and is associated with a
very poor prognosis. The standard treatment for newly diagnosed patients involves total …

DNA topoisomerase I plays a key role in lubricating the wheels of DNA replication or RNA
transcription through breaking and reconnecting DNA single-strand. It is widely known that …

Localized intra-periodontal pocket drug delivery using an injectable in situ forming gel is an
effective periodontitis treatment. The aqueous insoluble property of rosin is suitable for …

Malignant gliomas (MGs) are the most common and devastating primary brain tumor. At
present, surgical interventions, radiotherapy, and chemotherapy are only marginally …

Introduction: Recent studies showed that rapamycin, as a mammalian target of rapamycin
(mTOR) inhibitor, could have beneficial therapeutic effects for the central nervous system …

Glioblastoma (GBM) is the most aggressive and fatal brain tumor, with approximately 10,000
people diagnosed every year in the United States alone. The typical survival period for …

One of the challenges in developing sustained-release local drug delivery systems is the
limited treatment volume that can be achieved. In this work, we examine the effectiveness of …

The control of initial burst release of drugs from polymeric depots is a promising approach to
achieve the dose level of therapeutic agents after administration. This study describes the …

The objective of this work was to develop self-forming doxorubicin-loaded polymeric depots
as an injectable drug delivery system for liver cancer chemotherapy and studied the release …

Despite ongoing advancements in the field of medicine, glioblastoma multiforme (GBM) is
presently incurable, making this advanced brain tumor the deadliest tumor type in the central …