The human genetic epidemiology of COVID-19

MEK Niemi, MJ Daly, A Ganna - Nature Reviews Genetics, 2022 - nature.com
Human genetics can inform the biology and epidemiology of coronavirus disease 2019
(COVID-19) by pinpointing causal mechanisms that explain why some individuals become …

Genetic polymorphisms associated with susceptibility to COVID-19 disease and severity: A systematic review and meta-analysis

C Dieter, LA Brondani, CB Leitão, F Gerchman… - PLoS …, 2022 - journals.plos.org
Although advanced age and presence of comorbidities significantly impact the variation
observed in the clinical symptoms of COVID-19, it has been suggested that genetic variants …

Risk of Covid-19 severe outcomes and mortality in migrants and ethnic minorities compared to the general population in the European WHO region: a systematic …

E Mazzalai, D Giannini, ME Tosti, F D'Angelo… - Journal of International …, 2023 - Springer
The Covid-19 pandemic has had a major impact on migrants and ethnic minorities (MEMs).
Socio-economic factors and legal, administrative and language barriers are among the …

Association Between the LZTFL1 rs11385942 Polymorphism and COVID-19 Severity in Colombian Population

M Angulo-Aguado, D Corredor-Orlandelli… - Frontiers in …, 2022 - frontiersin.org
Genetic and non-genetic factors are responsible for the high interindividual variability in the
response to SARS-CoV-2. Although numerous genetic polymorphisms have been identified …

[HTML][HTML] Genetic susceptibility to severe COVID-19

C Cappadona, V Rimoldi, EM Paraboschi… - Infection, Genetics and …, 2023 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiologic agent of the
coronavirus disease 2019 (COVID-19) pandemic. Clinical manifestations of the disease …

Development and validation of a clinical and genetic model for predicting risk of severe COVID-19

GS Dite, NM Murphy, R Allman - Epidemiology & Infection, 2021 - cambridge.org
Clinical and genetic risk factors for severe coronavirus disease 2019 (COVID-19) are often
considered independently and without knowledge of the magnitudes of their effects on risk …

Leveraging the electronic health record to address the COVID-19 pandemic

BA Satterfield, O Dikilitas, IJ Kullo - Mayo Clinic Proceedings, 2021 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) pandemic continues its global spread.
Coordinated effort on a vast scale is required to halt its progression and to save lives …

Interplay between demographic, clinical and polygenic risk factors for severe COVID-19

SSR Crossfield, NJM Chaddock, MM Iles… - International Journal …, 2022 - academic.oup.com
Background We aimed to identify clinical, socio-demographic and genetic risk factors for
severe COVID-19 (hospitalization, critical care admission or death) in the general …

Predicting COVID-19 disease severity from SARS-CoV-2 spike protein sequence by mixed effects machine learning

BA Sokhansanj, GL Rosen - Computers in biology and medicine, 2022 - Elsevier
Epidemiological studies show that COVID-19 variants-of-concern, like Delta and Omicron,
pose different risks for severe disease, but they typically lack sequence-level information for …

[PDF][PDF] The impact of long-term conditions and comorbidity patterns on COVID-19 infection and hospitalisation: a cohort study

YT Huang, A Steptoe, RS Patel, E Fuller Thomson… - Gerontology, 2023 - karger.com
Introduction: Older adults are more vulnerable to COVID-19 infections; however, little is
known about which comorbidity patterns are related to a higher risk of COVID-19 infection …