The development of the reprogramming technology led to generation of induced Pluripotent
Stem Cells (iPSC) from a variety of somatic cells. Ever since, fast growing knowledge of …

Recent research in the field of inherited peripheral neuropathies (IPNs) such as Charcot–
Marie–Tooth (CMT) disease has helped identify the causative genes provided better …

Charcot-Marie-Tooth (CMT) disease is the most common inherited motor and sensory
neuropathy. The axonal form of the disease is designated as" CMT type 2"(CMT2). Although …

Hereditary motor and sensory neuropathy with proximal dominant involvement (HMSN-P) is
an autosomal-dominant neurodegenerative disorder characterized by widespread …

Hereditary spinal muscular atrophy is a motor neuron disorder characterized by muscle
weakness and atrophy due to degeneration of the anterior horn cells of the spinal cord …

Background: Previous studies have reported a high incidence of amyotrophic lateral
sclerosis (ALS) in endemic foci in the Kii Peninsula, Japan. However, little is known about …

Hyperlipidemia is a condition characterized by an elevation of any or all lipid profile and/or
lipoproteins in the blood. Although elevated low density lipoprotein cholesterol (LDL) is …

Charcot–Marie–Tooth disease constitutes a genetically heterogeneous group of hereditary
motor and sensory peripheral neuropathies. The axonal type of Charcot–Marie–Tooth is …

The early secretory pathway and autophagy are two essential and evolutionarily conserved
endomembrane processes that are finely interlinked. Although growing evidence suggests …

Abstract Charcot-Marie-Tooth disease (CMT) is one of the most common inherited
neuropathies and is both genetically and clinically heterogeneous, with variable inheritance …