Highlights•Examples of transgenerational epigenetic inheritance of brain related
phenotypes.•Overview of putative molecular carriers of non-genetic information are …

The early embryo is formed by the fusion of two germ cells that must generate not only all of
the nonreproductive somatic cell types of its body but also the germ cells for the next …

Methylation of histone H3K36 in higher eukaryotes is mediated by multiple
methyltransferases. Set2-related H3K36 methyltransferases are targeted to genes by …

We develop a statistical framework to study the relationship between chromatin features and
gene expression. This can be used to predict gene expression of protein coding genes, as …

Background The processes through which the germline maintains its continuity across
generations has long been the focus of biological research. Recent studies have suggested …

Background Germ cells must progress through elaborate developmental stages from an
undifferentiated germ cell to a fully differentiated gamete. Some of these stages include …

In animals, the germline is the only lineage that transmits genetic information to the next
generation. Although the founder cells of this lineage are specified differently in …

Although now dogma, the idea that nonvertebrate organisms such as yeast, worms, and flies
could inform, and in some cases even revolutionize, our understanding of oncogenesis in …

Chromatin regulators play important roles in the safeguarding of cell identities by opposing
the induction of ectopic cell fates and, thereby, preventing forced conversion of cell identities …

The germline of Caenorhabditis elegans derives from a single founder cell, the germline
blastomere P 4. P 4 is the product of four asymmetric cleavages that divide the zygote into …