Continuous Renal Replacement Therapy (CRRT) is more and more widely used in patients
for various indications recent years. It is still intricate for clinicians to decide a suitable …

Over the last several decades, antibacterial drug use has become widespread with their
misuse being an ever-increasing phenomenon. Consequently, antibacterial drugs have …

Introduction: The pharmacokinetic/pharmacodynamic index determining β-lactam activity is
the percentage of the dosing interval (% T) during which their free serum concentration …

Acute kidney injury represents a common complication in critically ill patients affected by
septic shock and in many cases continuous renal replacement therapy (CRRT) may be …

Sepsis is a leading cause of disability and mortality worldwide. The pathophysiology of
sepsis relies on the maladaptive host response to pathogens that fosters unbalanced organ …

Piperacillin-tazobactam is a potent β-lactam/β-lactamase inhibitor antibiotic commonly
prescribed in the intensive care unit setting. Admitted patients often show large variability in …

Critically ill patients with sepsis admitted to the intensive care unit (ICU) often present with or
develop renal dysfunction requiring renal replacement therapy (RRT) in addition to …

Several studies suggest that alternatives to carbapenems, and particulary beta-lactam/beta-
lactamase inhibitor combinations, can be used for therapy of extended-spectrum beta …

Our study aimed to describe the population pharmacokinetics (PK) of piperacillin and
tazobactam in patients on extracorporeal membrane oxygenation (ECMO), with and without …

Sub-optimal exposure to antimicrobial therapy is associated with poor patient outcomes and
the development of antimicrobial resistance. Mechanisms for optimizing the concentration of …