The extracellular matrix (ECM) plays a key role as both structural scaffold and regulator of
cell signal transduction in tissues. In times of ECM assembly and turnover, cells upregulate …

Many extracellular matrices (ECMs) have a filamentous architecture, which influences cell
growth and phenotype and imparts tissues with specific properties. Man-made fibrillar …

Fibronectin is an extracellular matrix protein that is present during periods of change within
tissues. It is upregulated and necessary in a number of developmental contexts, and it is …

Despite the crucial role of extracellular matrix (ECM) in directing cell fate in healthy and
diseased tissues—particularly in development, wound healing, tissue regeneration and …

Fibronectin (FN) is a ubiquitous extracellular matrix (ECM) glycoprotein that plays vital roles
during tissue repair. The plasma form of FN circulates in the blood, and upon tissue injury, is …

In the process of matrix assembly, multivalent extracellular matrix (ECM) proteins are
induced to self-associate and to interact with other ECM proteins to form fibrillar networks …

Integrin-mediated cell adhesions provide dynamic, bidirectional links between the
extracellular matrix and the cytoskeleton. Besides having central roles in cell migration and …

Fibronectin (FN) is a multidomain protein with the ability to bind simultaneously to cell
surface receptors, collagen, proteoglycans, and other FN molecules. Many of these domains …

Signaling and other cellular functions differ in three-dimensional compared with two-
dimensional systems. Cell adhesion structures can evolve in vitro towards in-vivo-like …

The extracellular matrix provides a framework for cell adhesion, supports cell movement,
and serves to compartmentalize tissues into functional units. Fibronectin is a core …