Humanized mouse models of clinical disease
NC Walsh, LL Kenney, S Jangalwe… - Annual Review of …, 2017 - annualreviews.org
Immunodeficient mice engrafted with functional human cells and tissues, that is, humanized
mice, have become increasingly important as small, preclinical animal models for the study …
mice, have become increasingly important as small, preclinical animal models for the study …
Hepatitis E virus: advances and challenges
At least 20 million hepatitis E virus (HEV) infections occur annually, with> 3 million
symptomatic cases and∼ 60,000 fatalities. Hepatitis E is generally self-limiting, with a case …
symptomatic cases and∼ 60,000 fatalities. Hepatitis E is generally self-limiting, with a case …
Humanized mice for immune system investigation: progress, promise and challenges
LD Shultz, MA Brehm, JV Garcia-Martinez… - Nature Reviews …, 2012 - nature.com
Significant advances in our understanding of the in vivo functions of human cells and tissues
and the human immune system have resulted from the development of'humanized'mouse …
and the human immune system have resulted from the development of'humanized'mouse …
TH1/TH2 paradigm extended: macrophage polarization as an unappreciated pathogen-driven escape mechanism?
E Muraille, O Leo, M Moser - Frontiers in immunology, 2014 - frontiersin.org
The classical view of the Th1/Th2 paradigm posits that the pathogen nature, infectious cycle,
and persistence represent key parameters controlling the choice of effector mechanisms …
and persistence represent key parameters controlling the choice of effector mechanisms …
Current advances in humanized mouse models
R Ito, T Takahashi, I Katano, M Ito - Cellular & molecular immunology, 2012 - nature.com
Humanized mouse models that have received human cells or tissue transplants are
extremely useful in basic and applied human disease research. Highly immunodeficient …
extremely useful in basic and applied human disease research. Highly immunodeficient …
Human hemato-lymphoid system mice: current use and future potential for medicine
To directly study complex human hemato-lymphoid system physiology and respective
system-associated diseases in vivo, human-to-mouse xenotransplantation models for …
system-associated diseases in vivo, human-to-mouse xenotransplantation models for …
Animal models of chronic liver diseases
Chronic liver diseases are frequent and potentially life threatening for humans. The
underlying etiologies are diverse, ranging from viral infections, autoimmune disorders, and …
underlying etiologies are diverse, ranging from viral infections, autoimmune disorders, and …
Hepatitis B virus infection and immunopathogenesis in a humanized mouse model: induction of human-specific liver fibrosis and M2-like macrophages
The mechanisms of chronic HBV infection and immunopathogenesis are poorly understood
due to a lack of a robust small animal model. Here we report the development of a …
due to a lack of a robust small animal model. Here we report the development of a …
Innovations, challenges, and minimal information for standardization of humanized mice
Mice xenotransplanted with human cells and/or expressing human gene products (also
known as “humanized mice”) recapitulate the human evolutionary specialization and …
known as “humanized mice”) recapitulate the human evolutionary specialization and …
[HTML][HTML] Hepatitis C virus in the new era: perspectives in epidemiology, prevention, diagnostics and predictors of response to therapy
F Ansaldi, A Orsi, L Sticchi, B Bruzzone… - World journal of …, 2014 - ncbi.nlm.nih.gov
Despite the great successes achieved in the fields of virology and diagnostics, several
difficulties affect improvements in hepatitis C virus (HCV) infection control and eradication in …
difficulties affect improvements in hepatitis C virus (HCV) infection control and eradication in …