Natural compounds as inhibitors of Aβ peptide aggregation: chemical requirements and molecular mechanisms
K Pagano, S Tomaselli, H Molinari… - Frontiers in …, 2020 - frontiersin.org
Alzheimer's disease (AD) is one of the most common neurodegenerative disorders, with no
cure and preventive therapy. Misfolding and extracellular aggregation of Amyloid-β (Aβ) …
cure and preventive therapy. Misfolding and extracellular aggregation of Amyloid-β (Aβ) …
Protein assembly and crowding simulations
Proteins encounter frequent molecular interactions in biological environments. Computer
simulations have become an increasingly important tool in providing mechanistic insights …
simulations have become an increasingly important tool in providing mechanistic insights …
Effect of electric field on α-synuclein fibrils: Revealed by molecular dynamics simulations
The self-association of amylogenic proteins to the fibril form is considered a pivotal factor in
the pathogenesis of neurodegenerative diseases, including Parkinson's disease (PD). PD …
the pathogenesis of neurodegenerative diseases, including Parkinson's disease (PD). PD …
Molecular dynamics simulations explore effects of electric field orientations on spike proteins of SARS-CoV-2 virions
Emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its
current worldwide spread have caused a pandemic of acute respiratory disease COVID-19 …
current worldwide spread have caused a pandemic of acute respiratory disease COVID-19 …
Exploring α-synuclein stability under the external electrostatic field: Effect of repeat unit
Parkinson's disease (PD) is a category of neurodegenerative disorders (ND) that currently
lack comprehensive and definitive treatment strategies. The etiology of PD can be attributed …
lack comprehensive and definitive treatment strategies. The etiology of PD can be attributed …
Conformational fluctuations and induced orientation of a protein, its solvation shell, and bulk water in weak non-unfolding external electric fields
Y Shuto, E Walinda, D Morimoto… - The Journal of Physical …, 2023 - ACS Publications
Extreme external electric fields have been reported to disrupt the tertiary structure of stably
folded proteins; however, the effects of weaker electric fields on many biomolecules …
folded proteins; however, the effects of weaker electric fields on many biomolecules …
Electromagnetic bioeffects: a multiscale molecular simulation perspective
Electromagnetic bioeffects remain an enigma from both the experimental and theoretical
perspectives despite the ubiquitous presence of related technologies in contemporary life …
perspectives despite the ubiquitous presence of related technologies in contemporary life …
The impact of natural compounds on S-shaped Aβ42 fibril: from molecular docking to biophysical characterization
The pursuit for effective strategies inhibiting the amyloidogenic process in
neurodegenerative disorders, such as Alzheimer's disease (AD), remains one of the main …
neurodegenerative disorders, such as Alzheimer's disease (AD), remains one of the main …
Understanding Osaka mutation polymorphic Aβ fibril response to static and oscillating electric fields: insights from computational modeling
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder, impacting millions of
individuals worldwide. Among its defining characteristics is the accumulation of senile …
individuals worldwide. Among its defining characteristics is the accumulation of senile …
[HTML][HTML] Characterization and kinetics of whey protein isolate amyloid fibril aggregates under moderate electric fields
RT Leal, RS Pereira, RM Rodrigues… - Food Research …, 2024 - Elsevier
Food proteins solutions enable the controlled flow of electrical current when subjected to a
Moderate electric field (MEF). This application results in internal heat generation, known as …
Moderate electric field (MEF). This application results in internal heat generation, known as …