[PDF][PDF] The immunobiology of the interleukin-12 family: room for discovery
The discovery of interleukin (IL)-6 and its receptor subunits provided a foundation to
understand the biology of a group of related cytokines: IL-12, IL-23, and IL-27. These family …
understand the biology of a group of related cytokines: IL-12, IL-23, and IL-27. These family …
Immunology of Mycobacterium tuberculosis Infections
JK Sia, J Rengarajan - Microbiology spectrum, 2019 - Am Soc Microbiol
Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …
Human IL-23 is essential for IFN-γ–dependent immunity to mycobacteria
Patients with autosomal recessive (AR) IL-12p40 or IL-12Rβ1 deficiency display Mendelian
susceptibility to mycobacterial disease (MSMD) due to impaired IFN-γ production and, less …
susceptibility to mycobacterial disease (MSMD) due to impaired IFN-γ production and, less …
IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases
MWL Teng, EP Bowman, JJ McElwee, MJ Smyth… - Nature medicine, 2015 - nature.com
Abstract The cytokine interleukin-12 (IL-12) was thought to have a central role in T cell–
mediated responses in inflammation for more than a decade after it was first identified …
mediated responses in inflammation for more than a decade after it was first identified …
Mendelian susceptibility to mycobacterial disease: genetic, immunological, and clinical features of inborn errors of IFN-γ immunity
Mendelian susceptibility to mycobacterial disease (MSMD) is a rare condition characterized
by predisposition to clinical disease caused by weakly virulent mycobacteria, such as BCG …
by predisposition to clinical disease caused by weakly virulent mycobacteria, such as BCG …
[HTML][HTML] STAT1 and its crucial role in the control of viral infections
The signal transducer and activator of transcription (STAT) 1 protein plays a key role in the
immune response against viruses and other pathogens by transducing, in the nucleus, the …
immune response against viruses and other pathogens by transducing, in the nucleus, the …
The role of IL-17A in axial spondyloarthritis and psoriatic arthritis: recent advances and controversies
DG McGonagle, IB McInnes, BW Kirkham… - Annals of the …, 2019 - ard.bmj.com
Although the pathogenic mechanisms underlying axial spondyloarthritis (axSpA) and
psoriatic arthritis (PsA) are not fully elucidated, several lines of evidence suggest that …
psoriatic arthritis (PsA) are not fully elucidated, several lines of evidence suggest that …
Interleukins, from 1 to 37, and interferon-γ: receptors, functions, and roles in diseases
M Akdis, S Burgler, R Crameri, T Eiwegger… - Journal of allergy and …, 2011 - Elsevier
Advancing our understanding of mechanisms of immune regulation in allergy, asthma,
autoimmune diseases, tumor development, organ transplantation, and chronic infections …
autoimmune diseases, tumor development, organ transplantation, and chronic infections …
The translation of non-canonical open reading frames controls mucosal immunity
The annotation of the mammalian protein-coding genome is incomplete. Arbitrary size
restriction of open reading frames (ORFs) and the absolute requirement for a methionine …
restriction of open reading frames (ORFs) and the absolute requirement for a methionine …
CD4 T cells: fates, functions, and faults
J Zhu, WE Paul - Blood, The Journal of the American Society of …, 2008 - ashpublications.org
Abstract In 1986, Mosmann and Coffman identified 2 subsets of activated CD4 T cells, Th1
and Th2 cells, which differed from each other in their pattern of cytokine production and their …
and Th2 cells, which differed from each other in their pattern of cytokine production and their …