The death morphology commonly known as apoptosis results from a post-translational pathway driven largely by specific limited proteolysis. In the last decade the structural basis …
The relatively common occurrence of sequences within proteins that match the consensus substrate specificity of caspases in intracellular proteins suggests a multitude of substrates …
G Klebe - Journal of molecular medicine, 2000 - Springer
Structure-based design has emerged as a new tool in medicinal chemistry. A prerequisite for this new approach is an understanding of the principles of molecular recognition in protein …
M Böhm, J Stürzebecher, G Klebe - Journal of medicinal chemistry, 1999 - ACS Publications
Three-dimensional quantitative structure− activity relationship (3D QSAR) methods were applied using a training set of 72 inhibitors of the benzamidine type with respect to their …
EW Davie - Journal of Biological Chemistry, 2003 - ASBMB
Being in the Neurath laboratory gave me an excellent chance to interact with his other graduate students and postdoctoral fellows. Individuals such as Leon Cunningham gave me …
MS Dennis, C Eigenbrot, NJ Skelton, MH Ultsch… - Nature, 2000 - nature.com
Potent anticoagulants have been derived by targeting the tissue factor–factor VIIa complex with naive peptide libraries displayed on M13 phage. The peptides specifically block the …
P Goettig, H Brandstetter, V Magdolen - Biochimie, 2019 - Elsevier
Trypsin and chymotrypsin-like serine proteases from family S1 (clan PA) constitute the largest protease group in humans and more generally in vertebrates. The prototypes …
M Riewald, VV Kravchenko, RJ Petrovan… - Blood, The Journal …, 2001 - ashpublications.org
Cell signaling by coagulation factor Xa (Xa) contributes to pro-inflammatory responses in vivo. This study characterizes the signaling mechanism of Xa in a HeLa cell line that …
W Bode - Blood Cells, Molecules, and Diseases, 2006 - Elsevier
Any vascular injury triggers the burst-like release of the trypsin-like serine proteinase α- thrombin. Thrombin, the main executioner of the coagulation cascade, exhibits procoagulant …