Metallo-β-lactamases in the age of multidrug resistance: from structure and mechanism to evolution, dissemination, and inhibitor design

G Bahr, LJ Gonzalez, AJ Vila - Chemical reviews, 2021 - ACS Publications
Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

Dynamic light scattering: a practical guide and applications in biomedical sciences

J Stetefeld, SA McKenna, TR Patel - Biophysical reviews, 2016 - Springer
Dynamic light scattering (DLS), also known as photon correlation spectroscopy (PCS), is a
very powerful tool for studying the diffusion behaviour of macromolecules in solution. The …

Clinical challenges treating Stenotrophomonas maltophilia infections: an update

MF Mojica, R Humphries, JJ Lipuma… - JAC-antimicrobial …, 2022 - academic.oup.com
Stenotrophomonas maltophilia is a non-fermenting, Gram-negative bacillus that has
emerged as an opportunistic nosocomial pathogen. Its intrinsic multidrug resistance makes …

β-lactam Resistance in Pseudomonas aeruginosa: Current Status, Future Prospects

KA Glen, IL Lamont - Pathogens, 2021 - mdpi.com
Pseudomonas aeruginosa is a major opportunistic pathogen, causing a wide range of acute
and chronic infections. β-lactam antibiotics including penicillins, carbapenems …

Evolutionary pathways and trajectories in antibiotic resistance

F Baquero, JL Martinez, V F. Lanza… - Clinical Microbiology …, 2021 - Am Soc Microbiol
Evolution is the hallmark of life. Descriptions of the evolution of microorganisms have
provided a wealth of information, but knowledge regarding “what happened” has precluded …

Serratia marcescens antibiotic resistance mechanisms of an opportunistic pathogen: a literature review

F Tavares-Carreon, K De Anda-Mora, IC Rojas-Barrera… - PeerJ, 2023 - peerj.com
Serratia marcescens is a ubiquitous bacterium from order Enterobacterales displaying a
high genetic plasticity that allows it to adapt and persist in multiple niches including soil …

Cell-wall recycling of the gram-negative bacteria and the nexus to antibiotic resistance

DA Dik, JF Fisher, S Mobashery - Chemical reviews, 2018 - ACS Publications
The importance of the cell wall to the viability of the bacterium is underscored by the breadth
of antibiotic structures that act by blocking key enzymes that are tasked with cell-wall …

Burkholderia cenocepacia Infections in Cystic Fibrosis Patients: Drug Resistance and Therapeutic Approaches

VC Scoffone, LR Chiarelli, G Trespidi… - Frontiers in …, 2017 - frontiersin.org
Burkholderia cenocepacia is an opportunistic pathogen particularly dangerous for cystic
fibrosis (CF) patients. It can cause a severe decline in CF lung function possibly developing …

Antibiotic resistance in Burkholderia species

KA Rhodes, HP Schweizer - Drug Resistance Updates, 2016 - Elsevier
The genus Burkholderia comprises metabolically diverse and adaptable Gram-negative
bacteria, which thrive in often adversarial environments. A few members of the genus are …

Lytic transglycosylases: concinnity in concision of the bacterial cell wall

DA Dik, DR Marous, JF Fisher… - Critical Reviews in …, 2017 - Taylor & Francis
The lytic transglycosylases (LTs) are bacterial enzymes that catalyze the non-hydrolytic
cleavage of the peptidoglycan structures of the bacterial cell wall. They are not catalysts of …