Intestinal stem cells at the bottom of crypts fuel the rapid renewal of the different cell types
that constitute a multitasking tissue. The intestinal epithelium facilitates selective uptake of …

Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

The Notch signalling cascade is an evolutionarily conserved pathway that has a crucial role
in regulating development and homeostasis in various tissues. The cellular processes and …

Due to its intense self-renewal kinetics and its simple repetitive architecture, the intestinal
epithelium has become a prime model for studying adult stem cells in health and disease …

Recent examples have highlighted how stem cells have the capability to initiate
morphogenesis in vitro; that is, to generate complex structures in culture that closely parallel …

The cancer stem cell (CSC) hypothesis has captured the attention of many scientists. It is
believed that elimination of CSCs could possibly eradicate the whole cancer. CSC surface …

Leucine-rich repeat-containing G-protein coupled receptor 5-positive (Lgr5+) stem cells
reside at crypt bottoms of the small and large intestine. Small intestinal Paneth cells supply …

Lgr5+ adult intestinal stem cells are highly proliferative throughout life. Single Lgr5+ stem
cells can be cultured into three-dimensional organoids containing all intestinal epithelial cell …

Colorectal cancer (CRC) has one of the highest mortality rates despite the advancement of
treatment options. Aggressive CRC remains difficult to treat owing to the activation of …

The intestinal epithelium is a rapidly renewing cellular compartment. This constant
regeneration is a hallmark of intestinal homeostasis and requires a tightly regulated balance …