In vascular beds, a potent vasoconstrictor of endothelin-1 (ET-1) is produced by endothelial
cells and released preferentially to the basal side of endothelial cells. It acts on endothelial …

It has been considered for a long time that the vascular endothelium is a simple barrier
which prevents direct contact between blood cells and the tissue of the vascular wall …

Congestive heart failure (CHF) is characterized by impaired left ventricular function,
increased peripheral and pulmonary vascular resistance and reduced exercise tolerance …

Although endothelin (ET) was discovered as a potent vascular endothelium-derived
constricting peptide, its presumed physiological and pathophysiological roles are now …

The vascular endothelium plays a fundamental role in the basal and dynamic regulation of
the circulation. Thus, it has a crucial role in the pathogenesis of hypertension. A spectrum of …

In summary, ET may be important in the pathogenesis of multiple diseases of the kidney.
Alterations in ET-1 production and action may lead to severe vasoconstriction, mesangial …

The vascular endothelium synthesizes and releases a spectrum of vasoactive substances
like nitric oxide (NO) and endothelin (ET). In hypertension, the delicate balance of …

Abstract THIS REVIEW UPDATES the current status of endothelin receptor antagonists in
the treatment of cerebral vasospasm. Recent preclinical and clinical studies are reviewed …

Endothelins are a family of structurally related, potent, long-lasting vasoconstrictor peptides.
There are no established normal human levels of endothelin-1 or endothelin-3 in the …

Endothelin, a potent vasoconstrictor peptide synthesized by the vascular smooth muscle
endothelium, was chronically infused into male Sprague-Dawley rats to determine whether a …