Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A
The normally antiviral enzyme APOBEC3A is an endogenous mutagen in human cancer. Its
single-stranded DNA C-to-U editing activity results in multiple mutagenic outcomes including …
single-stranded DNA C-to-U editing activity results in multiple mutagenic outcomes including …
Seven-membered ring nucleobases as inhibitors of human cytidine deaminase and APOBEC3A
The APOBEC3 (APOBEC3A-H) enzyme family as a part of the human innate immune system
deaminates cytosine to uracil in single-stranded DNA (ssDNA) and thereby prevents the …
deaminates cytosine to uracil in single-stranded DNA (ssDNA) and thereby prevents the …
Molecular mechanism for regulating APOBEC3G DNA editing function by the non-catalytic domain
APOBEC3G, part of the AID/APOBEC cytidine deaminase family, is crucial for antiviral
immunity. It has two zinc-coordinated cytidine-deaminase domains. The non-catalytic N …
immunity. It has two zinc-coordinated cytidine-deaminase domains. The non-catalytic N …
Deciphering the role of Enterococcus faecium cytidine deaminase in gemcitabine resistance of gallbladder cancer
L Jiang, L Zhang, Y Shu, Y Zhang, L Gao, S Qiu… - Journal of Biological …, 2024 - ASBMB
Gemcitabine-based chemotherapy is a cornerstone of standard care for gallbladder cancer
(GBC) treatment. Still, drug resistance remains a significant challenge, influenced by factors …
(GBC) treatment. Still, drug resistance remains a significant challenge, influenced by factors …
Small-Angle X-ray Scattering (SAXS) Measurements of APOBEC3G Provide Structural Basis for Binding of Single-Stranded DNA and Processivity
APOBEC3 enzymes are polynucleotide deaminases, converting cytosine to uracil on single-
stranded DNA (ssDNA) and RNA as part of the innate immune response against viruses and …
stranded DNA (ssDNA) and RNA as part of the innate immune response against viruses and …
Efficient convergent synthesis of 1, 3-diazepinone nucleosides by ring-closing metathesis and direct glycosylation
A new and highly efficient ring-closing metathesis-based strategy was developed for the
synthesis of the cyclic urea 1, 3-diazepinone, presenting significant improvement upon …
synthesis of the cyclic urea 1, 3-diazepinone, presenting significant improvement upon …
[HTML][HTML] Affinity Tag-Free Purification of SARS-CoV-2 N Protein and Its Crystal Structure in Complex with ssDNA
A Maiti, H Matsuo - Biomolecules, 2024 - pmc.ncbi.nlm.nih.gov
The nucleocapsid (N) protein is one of the four structural proteins in SARS-CoV-2, playing
key roles in viral assembly, immune evasion, and stability. One of its primary functions is to …
key roles in viral assembly, immune evasion, and stability. One of its primary functions is to …
Next generation APOBEC3 inhibitors: Optimally designed for potency and nuclease stability
APOBEC3 (or A3) enzymes have emerged as potential therapeutic targets due to their role
in introducing heterogeneity in viruses and cancer, often leading to drug resistance …
in introducing heterogeneity in viruses and cancer, often leading to drug resistance …
Synthesis of 1, 4-azaphosphinine nucleosides and evaluation as inhibitors of human cytidine deaminase and APOBEC3A
Nucleoside and polynucleotide cytidine deaminases (CDAs), such as CDA and APOBEC3,
share a similar mechanism of cytosine to uracil conversion. In 1984, phosphapyrimidine …
share a similar mechanism of cytosine to uracil conversion. In 1984, phosphapyrimidine …
Cross-linked DNA with carbazole pseudo-nucleoside enables potent inhibition of the cancer DNA-and RNA-mutating enzyme APOBEC3A
The human antiviral enzyme APOBEC3A has mutagenic activity in many human cancers,
where it is used to fuel tumour evolution. Its single-stranded DNA and RNA C-to-U editing …
where it is used to fuel tumour evolution. Its single-stranded DNA and RNA C-to-U editing …