Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

Chronic low-grade inflammation in adipose tissue (AT) is a hallmark of obesity and
contributes to various metabolic disorders, such as type 2 diabetes and cardiovascular …

Despite rapid progresses in the genome-editing field, in vivo simultaneous overexpression
of multiple genes remains challenging. We generated a transgenic mouse using an …

Metabolic syndrome poses a major threat on human health affecting the quality of life.
Adipose tissue is an important organ which plays a crucial role in the pathogenesis of …

Ageing is accompanied by altered intercellular communication, deregulated metabolic
function, and inflammation. Interventions that restore a youthful state delay or reverse these …

Activating beige adipocytes in white adipose tissue (WAT) to increase energy expenditure is
a promising strategy to combat obesity. We identified that mesencephalic astrocyte–derived …

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a novel evolutionarily
conserved protein present in both vertebrate and invertebrate species. MANF shows distinct …

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum-
resident protein and a secretory factor and has beneficial effects in multiple diseases …

Mesencephalic astrocyte-derived neurotrophic factor (MANF) and cerebral dopamine
neurotrophic factor (CDNF) are endoplasmic reticulum (ER) luminal proteins that confer …

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum
(ER) protein that can be secreted and protects dopamine neurons and cardiomyocytes from …