Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets
V Kumar - International immunopharmacology, 2020 - Elsevier
Cytokine storm generates during various systemic acute infections, including sepsis and
current pandemic called COVID-19 (severe) causing devastating inflammatory conditions …
current pandemic called COVID-19 (severe) causing devastating inflammatory conditions …
Metal drugs and the anticancer immune response
B Englinger, C Pirker, P Heffeter, A Terenzi… - Chemical …, 2018 - ACS Publications
The immune system deploys a multitude of innate and adaptive mechanisms not only to
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …
ward off pathogens but also to prevent malignant transformation (“immune surveillance”) …
[HTML][HTML] Pain regulation by gut microbiota: molecular mechanisms and therapeutic potential
The relationship between gut microbiota and neurological diseases, including chronic pain,
has received increasing attention. The gut microbiome is a crucial modulator of visceral …
has received increasing attention. The gut microbiome is a crucial modulator of visceral …
Small-molecule modulators of toll-like receptors
Conspectus Toll-like receptors (TLRs) are the “gatekeepers” of the immune system in
humans and other animals to protect the host from invading bacteria, viruses, and other …
humans and other animals to protect the host from invading bacteria, viruses, and other …
Toll-like receptor 4 (TLR4)/opioid receptor pathway crosstalk and impact on opioid analgesia, immune function, and gastrointestinal motility
P Zhang, M Yang, C Chen, L Liu, X Wei… - Frontiers in …, 2020 - frontiersin.org
Toll-like receptor 4 (TLR4) recognizes exogenous pathogen-associated molecular patterns
(PAMPs) and endogenous danger-associated molecular patterns (DAMPs) and initiates the …
(PAMPs) and endogenous danger-associated molecular patterns (DAMPs) and initiates the …
Toll-like receptors and their role in persistent pain
MJ Lacagnina, LR Watkins, PM Grace - Pharmacology & therapeutics, 2018 - Elsevier
One of the fundamental mechanisms whereby the innate immune system coordinates
inflammatory signal transduction is through Toll-like receptors (TLRs), which function to …
inflammatory signal transduction is through Toll-like receptors (TLRs), which function to …
Oncopreventive and oncotherapeutic potential of licorice triterpenoid compound glycyrrhizin and its derivatives: Molecular insights
R Jain, MA Hussein, S Pierce, C Martens… - Pharmacological …, 2022 - Elsevier
Licorice (Glycyrrhiza glabra) is a well-known natural herb used to treat different ailments
since ancient times. Glycyrrhizin (GL), which is the primary triterpenoid compound of licorice …
since ancient times. Glycyrrhizin (GL), which is the primary triterpenoid compound of licorice …
Macrophage toll-like receptor 9 contributes to chemotherapy-induced neuropathic pain in male mice
Chemotherapy-induced peripheral neuropathy (CIPN) remains a pressing clinical problem;
however, our understanding of sexual dimorphism in CIPN remains unclear. Emerging …
however, our understanding of sexual dimorphism in CIPN remains unclear. Emerging …
Sensory Neuron TLR4 mediates the development of nerve-injury induced mechanical hypersensitivity in female mice
TA Szabo-Pardi, LR Barron, ME Lenert… - Brain, behavior, and …, 2021 - Elsevier
Recent studies have brought to light the necessity to discern sex-specific differences in
various pain states and different cell-types that mediate these differences. These studies …
various pain states and different cell-types that mediate these differences. These studies …
[HTML][HTML] HMGB1 protein as a novel target for cancer
Highly conserved nuclear protein High Mobility Group Box1 (HMGB1) present in mammals
has functionality as an immuno-modulator in the form of cytokine molecule, as a nuclear …
has functionality as an immuno-modulator in the form of cytokine molecule, as a nuclear …