Targeting the EphA2 pathway: could it be the way for bone sarcomas?
G Giordano, C Tucciarello, A Merlini, S Cutrupi… - Cell Communication and …, 2024 - Springer
Bone sarcomas are malignant tumors of mesenchymal origin. Complete surgical resection is
the cornerstone of multidisciplinary treatment. However, advanced, unresectable forms …
the cornerstone of multidisciplinary treatment. However, advanced, unresectable forms …
Structural and functional insights into the transmembrane domain association of Eph receptors
Eph receptors are the largest family of receptor tyrosine kinases and by interactions with
ephrin ligands mediate a myriad of processes from embryonic development to adult tissue …
ephrin ligands mediate a myriad of processes from embryonic development to adult tissue …
Transmembrane dimers of type 1 receptors sample alternate configurations: MD simulations using coarse grain Martini 3 versus AlphaFold2 Multimer
Structures and dynamics of transmembrane (TM) receptor regions are key to understanding
their signaling mechanism across membranes. Here we examine configurations of TM …
their signaling mechanism across membranes. Here we examine configurations of TM …
Spiers Memorial Lecture: Analysis and de novo design of membrane-interactive peptides
Membrane–peptide interactions play critical roles in many cellular and organismic functions,
including protection from infection, remodeling of membranes, signaling, and ion transport …
including protection from infection, remodeling of membranes, signaling, and ion transport …
[HTML][HTML] Transmembrane helix interactions regulate oligomerization of the receptor tyrosine kinase EphA2
The transmembrane helices of receptor tyrosine kinases (RTKs) have been proposed to
switch between two different dimeric conformations, one associated with the inactive RTK …
switch between two different dimeric conformations, one associated with the inactive RTK …
Allosteric inhibition of the T cell receptor by a designed membrane ligand
The T cell receptor (TCR) is a complex molecular machine that directs the activation of T
cells, allowing the immune system to fight pathogens and cancer cells. Despite decades of …
cells, allowing the immune system to fight pathogens and cancer cells. Despite decades of …
Immunohistochemical expression of ephrin receptors in neuroendocrine neoplasms: a case-series of gastroenteropancreatic neuroendocrine neoplasms and a …
KI Alexandraki, E Papadimitriou, A Spyroglou… - Endocrine, 2024 - Springer
Purpose Erythropoietin-producing hepatocellular (EPH) receptors are the largest known
family of tyrosine kinases receptors (TKR) in humans, implicated in cell proliferation …
family of tyrosine kinases receptors (TKR) in humans, implicated in cell proliferation …
Allosteric inhibition of the epidermal growth factor receptor through disruption of transmembrane interactions
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (RTK) commonly
targeted for inhibition by anticancer therapeutics. Current therapeutics target EGFR's kinase …
targeted for inhibition by anticancer therapeutics. Current therapeutics target EGFR's kinase …
Cholesterol-Dependent Dimerization and Conformational Dynamics of EphA2 Receptors: Insights from Coarse-Grained and All-Atom Simulations
The EphA2 transmembrane receptor is a key regulator of cellular growth, differentiation, and
motility, and its overexpression in various cancers positions it as a promising biomarker for …
motility, and its overexpression in various cancers positions it as a promising biomarker for …
Simulation of neurotrophin receptor transmembrane helix interactions reveals active states and distinct signaling mechanisms
C Athanasiou, A Claveras Cabezudo, A Tsengenes… - bioRxiv, 2024 - biorxiv.org
Neurotrophin (NT) receptor signaling regulates neuronal survival, axonal and dendritic
network maintenance, differentiation, and synaptic plasticity. Signaling is initiated by NT …
network maintenance, differentiation, and synaptic plasticity. Signaling is initiated by NT …