The presence of phospholipids as a component of chromatin is now well documented and
many enzymes such as sphingomyelinase, sphingomyelin-synthase, reverse sphingomyelin …

Diacylglycerols are second messengers confined to biomembranes and, although relatively
simple molecules from the structural point of view, they are able of triggering a surprisingly …

It is known that nuclear lipids play a role in proliferation, differentiation, and apoptotic
process. Cellular nuclei contain high levels of phosphatidylcholine and sphingomyelin …

The vast majority of primary human breast cancer tissues display aberrant nuclear NF-κB c-
Rel expression. A causal role for c-Rel in mammary tumorigenesis has been demonstrated …

Aim: To understand the contribution of sphingolipid metabolism and its metabolites to
development and aging. Methods: A systemic analysis on the changes in activity of …

The increased sphingolipid turnover in the liver is associated with elevation of free radical
production and state of chronic inflammation at old age. Plant polyphenols are reported to …

It is known that phospholipids represent a minor component of chromatin. It has been
highlighted recently that these lipids are metabolized directly inside the nucleus, thanks to …

An increase of the neutral sphingomyelinase (SMase) activity in the animal brain at old age
is associated with a higher expression of the inflammatory marker, interleukin-1β and a …

Intranuclear lipid metabolism modifications in relation to cell proliferation and/or apoptosis
were demonstrated in hepatocytes. The aim of this study was to establish whether nuclear …

Ceramides are a novel class of biologically active molecules involved in the regulation of
different signaling pathways. Ceramide is involved in regulation of the phospholipase D …