Thiazole: A versatile standalone moiety contributing to the development of various drugs and biologically active agents

MF Arshad, A Alam, AA Alshammari, MB Alhazza… - Molecules, 2022 - mdpi.com
For many decades, the thiazole moiety has been an important heterocycle in the world of
chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) …

Pathogenicity and virulence of influenza

Y Liang - Virulence, 2023 - Taylor & Francis
Influenza viruses, including four major types (A, B, C, and D), can cause mild-to-severe and
lethal diseases in humans and animals. Influenza viruses evolve rapidly through antigenic …

The Chinese prescription lianhuaqingwen capsule exerts anti-influenza activity through the inhibition of viral propagation and impacts immune function

Y Ding, L Zeng, R Li, Q Chen, B Zhou, Q Chen… - … and alternative medicine, 2017 - Springer
Abstract Background Lianhuaqingwen Capsule (LH-C) is a traditional Chinese medicine
(TCM) formula used to treat respiratory tract infectious diseases in Chinese. The aim of this …

The influenza virus polymerase complex: an update on its structure, functions, and significance for antiviral drug design

A Stevaert, L Naesens - Medicinal research reviews, 2016 - Wiley Online Library
Influenza viruses cause seasonal epidemics and pandemic outbreaks associated with
significant morbidity and mortality, and a huge cost. Since resistance to the existing anti …

[HTML][HTML] Andrographolide inhibits influenza A virus-induced inflammation in a murine model through NF-κB and JAK-STAT signaling pathway

Y Ding, L Chen, W Wu, J Yang, Z Yang, S Liu - Microbes and infection, 2017 - Elsevier
Influenza viruses, the main cause of respiratory tract diseases, cause high morbidity and
mortality in humans. Excessive inflammation in the lungs is proposed to be a hallmark for the …

1, 8-Cineol protect against influenza-virus-induced pneumonia in mice

Y Li, Y Lai, Y Wang, N Liu, F Zhang, P Xu - Inflammation, 2016 - Springer
Cineol is a major monoterpene principally from eucalyptus essential oils and has been
shown to exert anti-inflammatory, antiviral, and inhibitory of nuclear factor (NF)-kB effect. In …

Influenza virus infections and cellular kinases

R Meineke, GF Rimmelzwaan, H Elbahesh - Viruses, 2019 - mdpi.com
Influenza A viruses (IAVs) are a major cause of respiratory illness and are responsible for
yearly epidemics associated with more than 500,000 annual deaths globally. Novel IAVs …

Could a lower toll-like receptor (TLR) and NF-κB activation due to a changed charge distribution in the spike protein be the reason for the lower pathogenicity of …

R Kircheis, O Planz - International Journal of Molecular Sciences, 2022 - mdpi.com
The novel SARS-CoV-2 Omicron variant B. 1.1. 529, which emerged in late 2021, is
currently active worldwide, replacing other variants, including the Delta variant, due to an …

[HTML][HTML] New drug-strategies to tackle viral-host interactions for the treatment of influenza virus infections

SI van de Wakker, MJE Fischer, RS Oosting - European journal of …, 2017 - Elsevier
The influenza virus (IV) is a highly contagious virus causing seasonal global outbreaks
affecting annually up to 20% of the world's population and leading to 250,000–500,000 …

Chemical space mapping and structure–activity analysis of the ChEMBL antiviral compound set

K Klimenko, G Marcou, D Horvath… - Journal of chemical …, 2016 - ACS Publications
Curation, standardization and data fusion of the antiviral information present in the ChEMBL
public database led to the definition of a robust data set, providing an association of antiviral …