The crucial role of CD4+ and CD8+ T cells in shaping and controlling immune responses
during immune disease and cancer development has been well established and used to …

Simple Summary Over the past decade, cell-based immunotherapy has become a powerful
strategy in solid cancer therapy. Tumor-infiltrating lymphocytes (TILs) are a group of …

Administration of bispecific antibodies (biAbs) in tumor therapy is limited by their short half-
life and off-target toxicity. Optimized strategies or targets are needed to overcome these …

Adoptive cell therapy (ACT) using autologous tumor-infiltrating lymphocytes (TIL) has been
tested in advanced melanoma patients at various centers. We conducted a systematic …

Abstract 2019 coronavirus disease (COVID‐19) presents as a newly recognized pneumonia
and could rapidly progress into acute respiratory distress syndrome which has brought …

Glioblastomas are aggressive, fast-growing primary brain tumors. After standard-of-care
treatment with radiation in combination with temozolomide, the overall prognosis of newly …

The ecosystem of brain tumors is considered immunosuppressed, but our current
knowledge may be incomplete. Here we analyzed clinical cell and tissue specimens derived …

Gliomas are the most aggressive primary intracranial malignancies with poor overall
survival. ITGA5 is one member of the integrin adhesion molecule family and is implicated in …

The development of immunotherapies has revolutionized intervention strategies for a variety
of primary cancers. Despite this promising progress, treatment options for primary brain …

Chimeric antigen receptor (CAR) T cell therapy in glioblastoma faces many challenges
including insufficient CAR T cell abundance and antigen-negative tumor cells evading …