Melioidosis

WJ Wiersinga, HS Virk, AG Torres, BJ Currie… - Nature reviews Disease …, 2018 - nature.com
Burkholderia pseudomallei is a Gram-negative environmental bacterium and the
aetiological agent of melioidosis, a life-threatening infection that is estimated to account …

The bacterial epigenome

MA Sánchez-Romero, J Casadesús - Nature Reviews Microbiology, 2020 - nature.com
In all domains of life, genomes contain epigenetic information superimposed over the
nucleotide sequence. Epigenetic signals control DNA–protein interactions and can cause …

ConStrains identifies microbial strains in metagenomic datasets

C Luo, R Knight, H Siljander, M Knip, RJ Xavier… - Nature …, 2015 - nature.com
An important fraction of microbial diversity is harbored in strain individuality, so identification
of conspecific bacterial strains is imperative for improved understanding of microbial …

Global and regional dissemination and evolution of Burkholderia pseudomallei

C Chewapreecha, MTG Holden, M Vehkala… - Nature …, 2017 - nature.com
The environmental bacterium Burkholderia pseudomallei causes an estimated 165,000
cases of human melioidosis per year worldwide and is also classified as a biothreat agent …

Regulation of genetic flux between bacteria by restriction–modification systems

PH Oliveira, M Touchon… - Proceedings of the …, 2016 - National Acad Sciences
Restriction–modification (RM) systems are often regarded as bacteria's innate immune
systems, protecting cells from infection by mobile genetic elements (MGEs). Their …

Conserved DNA methyltransferases: a window into fundamental mechanisms of epigenetic regulation in bacteria

PH Oliveira, G Fang - Trends in microbiology, 2021 - cell.com
An increasing number of studies have reported that bacterial DNA methylation has important
functions beyond the roles in restriction-modification systems, including the ability of …

Human melioidosis

I Gassiep, M Armstrong, R Norton - Clinical microbiology reviews, 2020 - Am Soc Microbiol
The causative agent of melioidosis, Burkholderia pseudomallei, a tier 1 select agent, is
endemic in Southeast Asia and northern Australia, with increased incidence associated with …

Pathogenicity and virulence of Burkholderia pseudomallei

NM Bzdyl, CL Moran, J Bendo, M Sarkar-Tyson - Virulence, 2022 - Taylor & Francis
The soil saprophyte, Burkholderia pseudomallei, is the causative agent of melioidosis, a
disease endemic in South East Asia and northern Australia. Exposure to B. pseudomallei by …

Identification of the lipodepsipeptide selethramide encoded in a giant nonribosomal peptide synthetase from a Burkholderia bacterium

SB Romanowski, S Lee, S Kunakom… - Proceedings of the …, 2023 - National Acad Sciences
Bacterial natural products have found many important industrial applications. Yet traditional
discovery pipelines often prioritize individual natural product families despite the presence …

Impact of homologous recombination on the evolution of prokaryotic core genomes

P González-Torres, F Rodríguez-Mateos, J Antón… - MBio, 2019 - Am Soc Microbiol
Homologous recombination (HR) enables the exchange of genetic material between and
within species. Recent studies suggest that this process plays a major role in the …