Metabolites as signalling molecules

SA Baker, J Rutter - Nature reviews molecular cell Biology, 2023 - nature.com
Traditional views of cellular metabolism imply that it is passively adapted to meet the
demands of the cell. It is becoming increasingly clear, however, that metabolites do more …

The utility of peripheral blood leucocyte ratios as biomarkers in infectious diseases: A systematic review and meta-analysis

CD Russell, A Parajuli, HJ Gale, NS Bulteel… - Journal of Infection, 2019 - Elsevier
Objectives To assess the utility of the neutrophil: lymphocyte (NLR), lymphocyte: monocyte
(LMR) and platelet: lymphocyte ratios (PLR) as infection biomarkers. Methods …

Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021

L Evans, A Rhodes, W Alhazzani, M Antonelli… - Critical care …, 2021 - journals.lww.com
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

Neutrophil-to-lymphocyte ratio, past, present and future perspectives

R Zahorec - Bratisl Lek Listy, 2021 - search.ebscohost.com
In the review we analyzed short history of the establishment of a novel hematological
parameter for systemic inflammation and stress coined as a neutrophil to lymphocyte ratio …

The neutrophil–lymphocyte ratio and incident atherosclerotic events: analyses from five contemporary randomized trials

NH Adamstein, JG MacFadyen, LM Rose… - European heart …, 2021 - academic.oup.com
Aims The neutrophil–lymphocyte ratio (NLR) is a readily available inflammatory biomarker
that may associate with atherosclerosis and predict cardiovascular (CV) events. The aims of …

Neutrophil‐to‐lymphocyte ratio, monocyte‐to‐lymphocyte ratio, platelet‐to‐lymphocyte ratio, and mean platelet volume‐to‐platelet count ratio as biomarkers in …

D Djordjevic, G Rondovic, M Surbatovic… - Mediators of …, 2018 - Wiley Online Library
Background. Neutrophil‐to‐lymphocyte ratio (NLR), monocyte‐to‐lymphocyte ratio (MLR),
platelet‐to‐lymphocyte ratio (PLR), and mean platelet volume‐to‐platelet count (MPV/PC) …

Monocyte distribution width (MDW) performance as an early sepsis indicator in the emergency department: comparison with CRP and procalcitonin in a multicenter …

P Hausfater, N Robert Boter, C Morales Indiano… - Critical care, 2021 - Springer
Background Early sepsis diagnosis has emerged as one of the main challenges in the
emergency room. Measurement of sepsis biomarkers is largely used in current practice to …

[HTML][HTML] The complete blood count to diagnose septic shock

JD Farkas - Journal of thoracic disease, 2020 - ncbi.nlm.nih.gov
The complete blood count has a longstanding role in the diagnosis of septic shock. Despite
its limitations, this is a pragmatic tool because patients will generally have a blood count …

Monocyte distribution width: a novel indicator of sepsis-2 and sepsis-3 in high-risk emergency department patients

ED Crouser, JE Parrillo, CW Seymour… - Critical care …, 2019 - journals.lww.com
Objectives: Most septic patients are initially encountered in the emergency department
where sepsis recognition is often delayed, in part due to the lack of effective biomarkers …

Cytokines as potential biomarkers for differential diagnosis of sepsis and other non-septic disease conditions

A Frimpong, EDA Owusu, JA Amponsah… - Frontiers in Cellular …, 2022 - frontiersin.org
Sepsis defined as a dysregulated immune response is a major cause of morbidity in
children. In sub-Saharan Africa, the clinical features of sepsis overlap with other frequent …