Targeted protein degradation (TPD) is an emerging modality for research and therapeutics.
Most TPD approaches harness cellular ubiquitin-dependent proteolytic pathways …

A vast ensemble of extracellular proteins influences the development and progression of
cancer, shaped and reshaped by a complex network of extracellular proteases. These …

FAM111A, a serine protease, plays roles in DNA replication and antiviral defense. Missense
mutations in the catalytic domain cause hyper-autocleavage and are associated with genetic …

Serine hydrolases (SHs) comprise a large superfamily of enzymes that play critical roles in
many biological processes. Despite their importance, many SHs remain uncharacterized …

Understanding of the metabolic reprogramming has revolutionized our insights into tumor
progression and potential treatment. This review concentrates on the aberrant metabolic …

The integration of transcriptome and proteome analysis can lead to the discovery of a myriad
of biological insights into ovarian cancer. Proteome, clinical, and transcriptome data about …