The three sets of symptoms associated with schizophrenia—positive, negative, and
cognitive—are burdensome and have serious effects on public health, which affects up to …

Schizophrenia research has traditionally focused almost exclusively on how the brain
interprets the outside world. However, our internal bodily milieu is also central to how we …

Psychiatric diseases exact a heavy socioeconomic toll, and it is particularly difficult to identify
their risk factors and causative mechanisms due to their multifactorial nature, the limited …

Background Extensive observational evidence put forward the association between
psychiatric disorders and type 2 diabetes mellitus (T2DM). However, causal relationships …

As the global burden of mortality from COVID-19 continues to rise, an understanding of who
is most at risk of adverse outcomes is of paramount importance. Pre-existing …

Context Insomnia is associated with insulin resistance (IR) in observational studies;
however, whether insomnia is causally associated with IR remains unestablished. Objective …

Background Mental disorders are among the top causes of disease burden worldwide.
Existing evidence regarding the repurposing of antihypertensives for mental disorders …

Background Schizophrenia commonly co-occurs with cardiometabolic and inflammation-
related traits. It is unclear to what extent the comorbidity could be explained by shared …

Background: The association between inflammatory cytokines and osteoarthritis (OA) has
been reported in several observational studies, but the causal relationship between these …

Inflammatory phenomena are found in many psychiatric disorders—notably, depression,
schizophrenia, and posttraumatic stress disorder. Inflammation has been linked to severity …