Osteopontin (OPN) is a highly phosphorylated glycophosphoprotein having acidic
characteristics and rich in aspartic acid. OPN, a multifunctional protein, has important …

Incretin peptides, principally GLP-1 and GIP, regulate islet hormone secretion, glucose
concentrations, lipid metabolism, gut motility, appetite and body weight, and immune …

Type 2 diabetes (T2D) is a complex disease that is caused by a complex interplay between
genetic, epigenetic and environmental factors. While the major environmental factors, diet …

Through genome-wide association meta-analyses of up to 133,010 individuals of European
ancestry without diabetes, including individuals newly genotyped using the Metabochip, we …

Since its first description more than 20 years ago osteopontin has emerged as an active
player in many physiological and pathological processes, including biomineralization, tissue …

Until just a few years ago, the genetic determinants of obesity and metabolic syndrome were
largely unknown, with the exception of a few forms of monogenic extreme obesity. Since …

Background Glucose-dependent insulinotropic peptide (GIP) is one of two incretin hormones
that communicate nutrient intake with systemic metabolism. Although GIP was the first …

Although it has long been assumed that insulin resistance is the leading factor in the
pathogenesis of type 2 diabetes (1), evidence for the importance of the pancreatic β-cells …

The prevalence and incidence of type 2 diabetes, representing. 90% of all cases of diabetes,
are increasing rapidly throughout the world. The International Diabetes Federation has …

Antagonism or agonism of the glucose-dependent insulinotropic polypeptide (GIP) receptor
(GIPR) prevents weight gain and leads to dramatic weight loss in combination with glucagon …